Early Post-Natal Neuroactive Steroid Manipulation Modulates Ondansetron Effects on Initial Periods of Alcohol Consumption in Rats

    June 2018 in “ Physiology & behavior ”
    Iris Bartolomé, Anna Llidó, Sònia Darbra, Marc Pallarès
    Studysummary The study found that ondansetron decreased alcohol consumption only in adult rats that experienced altered neuroactive steroid levels from early post-natal finasteride exposure, suggesting increased 5HT3 receptor sensitivity in these rats.
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    Research cited in this study 9

    1. Effects of Neonatal and Adolescent Neuroactive Steroid Manipulation on Locomotor Activity Induced by Ethanol in Male Wistar Rats Behavioural brain research · 2017
    2. Neonatal Finasteride Administration Decreases Dopamine Release in Nucleus Accumbens After Alcohol and Food Presentation in Adult Male Rats Behavioural Brain Research · 2016
    3. Divergent Neuroactive Steroid Responses to Stress and Ethanol in Rat and Mouse Strains: Relevance for Human Studies Psychopharmacology · 2014
    4. Neonatal Finasteride Administration Alters Hippocampal α4 and δ GABAAR Subunits Expression and Behavioral Responses to Progesterone in Adult Rats The International Journal of Neuropsychopharmacology · 2013
    5. Neonatal Neurosteroid Levels Are Determinant in Shaping Adult Prepulse Inhibition Response to Hippocampal Allopregnanolone in Rats Psychoneuroendocrinology · 2013
    6. Alteration of Neonatal Allopregnanolone Levels Affects Exploration, Anxiety, Aversive Learning, and Adult Behavioral Response to Intrahippocampal Neurosteroids Behavioural Brain Research · 2012
    7. Alterations in Neonatal Neurosteroids Affect Exploration During Adolescence and Prepulse Inhibition in Adulthood Psychoneuroendocrinology · 2009
    8. The Neurosteroid Environment in the Hippocampus Exerts Bi-Directional Effects on Seizure Susceptibility in Mice Brain Research · 2008
    9. Studies on Neurosteroids XXV: Influence of a 5α-Reductase Inhibitor, Finasteride, on Rat Brain Neurosteroid Levels and Metabolism Biological & Pharmaceutical Bulletin · 2008