Increased Anxiety-Like Phenotype in Female Guinea Pigs Following Reduced Neurosteroid Exposure In Utero

    February 2017 in “ International journal of developmental neuroscience ”
    Angela Cumberland, Hannah K. Palliser, Gabrielle K. Crombie … Jonathan J. Hirst
    Studysummary This study observed that reduced in utero exposure to the neurosteroid allopregnanolone increased anxiety-like behavior in female guinea pigs during the juvenile period without affecting long-term allopregnanolone levels.
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    Research cited in this study 7

    1. Neonatal Neurosteroid Levels Are Determinant in Shaping Adult Prepulse Inhibition Response to Hippocampal Allopregnanolone in Rats Psychoneuroendocrinology · 2013
    2. Interaction Between Early Postnatal Neurosteroid Manipulations and Adult Infusion of Neurosteroids Into CA1 Hippocampal Region on the Open Field Behavior Behavioural Brain Research · 2010
    3. Neuroactive Steroids Induce Changes in Fetal Sheep Behavior During Normoxic and Asphyxic States Stress · 2010
    4. Role of Neurosteroids in Regulating Cell Death and Proliferation in the Late Gestation Fetal Brain Neuroscience · 2009
    5. Changes in Progesterone Metabolites in the Hippocampus Can Modulate Open Field and Forced Swim Test Behavior of Proestrous Rats Hormones and Behavior · 2002
    6. Effect of Finasteride on Behavioral Arousal and Somatosensory Evoked Potentials in Fetal Sheep Neuroscience Letters · 2001
    7. Effects of Finasteride, a 5 Alpha-Reductase Inhibitor, on Circulating Androgens and Gonadotropin Secretion in Hirsute Women The Journal of Clinical Endocrinology and Metabolism · 1994