Involvement of Neurosteroids in the Control of Prolactin Secretion in Sheep Under Basal, Stressful and Pregnancy Conditions

    August 2022 in “ Theriogenology ”
    Elżbieta Marciniak, Patrycja Młotkowska, Katarzyna Roszkowicz-Ostrowska, Ewa Ciska, Tomasz Misztal
    TLDR Neurosteroids affect prolactin levels in sheep differently depending on stress and pregnancy conditions.
    This study investigated the role of neurosteroids in regulating prolactin (PRL) secretion in sheep under basal, stressful, and pregnancy conditions. In Experiment 1, 24 luteal-phase sheep were divided into control and allopregnanolone (AL) infusion groups, with half of each group subjected to stress. AL increased PRL mRNA expression but inhibited PRL release in stressed sheep. In Experiment 2, 12 pregnant sheep received control or finasteride infusions, which transiently increased plasma PRL levels. The findings suggest that neurosteroids like AL have a bimodal effect on PRL secretion, stimulating mRNA expression while inhibiting hormone release, and that these effects vary under different physiological conditions.
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