Involvement of Neurosteroids in the Control of Prolactin Secretion in Sheep Under Basal, Stressful and Pregnancy Conditions

    August 2022 in “ Theriogenology ”
    Elżbieta Marciniak, Patrycja Młotkowska, Katarzyna Roszkowicz-Ostrowska, Ewa Ciska, Tomasz Misztal
    TLDR Neurosteroids affect prolactin levels in sheep differently depending on stress and pregnancy conditions.
    This study investigated the role of neurosteroids in regulating prolactin (PRL) secretion in sheep under basal, stressful, and pregnancy conditions. In Experiment 1, 24 luteal-phase sheep were divided into control and allopregnanolone (AL) infusion groups, with half of each group subjected to stress. AL increased PRL mRNA expression but inhibited PRL release in stressed sheep. In Experiment 2, 12 pregnant sheep received control or finasteride infusions, which transiently increased plasma PRL levels. The findings suggest that neurosteroids like AL have a bimodal effect on PRL secretion, stimulating mRNA expression while inhibiting hormone release, and that these effects vary under different physiological conditions.
    Discuss this study in the Community →

    Research cited in this study

    1 / 1 results

    Related Community Posts Join

    6 / 129 results

      community I've been afflicted by post finasteride syndrome, what now?

      in Finasteride  42 upvotes 5 years ago
      A user experienced severe side effects from finasteride, including mental health issues and physical symptoms, and sought advice on managing post-finasteride syndrome. Suggestions included checking vitamin levels, considering dopamine agonists, and avoiding further psychiatric medications.

      community DHT and 5AR respect post, it's importance within the brain

      in Research/Science  111 upvotes 9 months ago
      The conversation discusses whether to use finasteride for hair loss, considering its role in inhibiting DHT and 5AR, which can affect brain function and mood. Some users report anxiety and depression from finasteride, while others do not experience these side effects and emphasize the importance of DHT for brain and prostate health.

      community Finastride is a god send miracle FOR ME

      in Finasteride/Dutasteride  203 upvotes 2 years ago
      . This user experienced positive results from using a combination of minoxidil and finasteride, with no reported side effects after two months. Others have also shared their experiences with both short-term and long-term use of finasteride.

      community Trestolone (MENT) as a nuclear treatment

      in Treatment  99 upvotes 2 years ago
      Experimenting with trestolone as a treatment for hair loss in an attempt to avoid DHT-related treatments such as finasteride and dutasteride, and discussing the potential effects of its receptor selectivity on the androgen receptors in the scalp.

    Related Research

    1 / 1 results