Effect of Neurosteroids on Basal and Stress-Induced Oxytocin Secretion in Luteal-Phase and Pregnant Sheep

May 2023 in “ Animals ”

Patrycja Młotkowska, Elżbieta Marciniak, Anna Misztal, Tomasz Misztal

neurosteroids oxytocin luteal-phase pregnant sheep allopregnanolone finasteride stress-induced secretion basal secretion neurosteroid synthesis OT AL Propecia

TLDR Neurosteroids help regulate oxytocin levels, especially during stress and pregnancy, to protect against premature labor.

This study examined the effects of neurosteroids on oxytocin (OT) secretion in 36 luteal-phase and pregnant sheep under basal and stress conditions. Allopregnanolone (AL) was found to inhibit stress-induced OT secretion in non-pregnant sheep, while blocking neurosteroid synthesis with finasteride increased both basal and stress-induced OT secretion in pregnant sheep. The results suggest that neurosteroids play a crucial role in regulating OT secretion, particularly under stress and pregnancy conditions, potentially protecting the fetus from premature labor.

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Research cited in this study

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Involvement of Neurosteroids in the Control of Hypothalamic-Pituitary-Adrenal Axis Activity in Pregnant Sheep Under Basal and Stressful Conditions

research Involvement of Neurosteroids in the Control of Hypothalamic-Pituitary-Adrenal Axis Activity in Pregnant Sheep Under Basal and Stressful Conditions

4 citations, August 2021 in “Theriogenology”

Neurosteroids play a key role in controlling the brain-adrenal gland activity in pregnant sheep, both in normal and stressful situations.

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research Effect of Neurosteroids on Basal and Stress-Induced Oxytocin Secretion in Luteal-Phase and Pregnant Sheep

May 2023 in “Animals”

Neurosteroids help regulate oxytocin levels, especially during stress and pregnancy, to protect against premature labor.