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The skin systems of jawed vertebrates evolved diverse appendages like hair and scales from a common structure over 420 million years ago.

Hair aging is caused by stress, hormones, inflammation, and DNA damage affecting hair growth and color.

Changing hair follicle identity could potentially reverse balding.

Aging mice have slower hair regeneration due to changes in signal balance, but the environment, not stem cell loss, controls this, suggesting treatments could focus on environmental factors.

Aconiti Ciliare Tuber extract may help hair grow by activating a specific cell signaling pathway.

The type 3 IP3 receptor is important for controlling hair loss and growth.

Scientists are using clumps of special stem cells to improve organ repair.

Stress can worsen skin and hair conditions by affecting the skin's immune response and hormone levels.

Hair follicles help absorb and store topical compounds, aiding targeted drug delivery.

Jumonji genes are important for development and their mutations can cause abnormalities, especially in the heart and brain.

μ-opiate receptors in skin cells may affect skin health and healing.

Versican, a protein, is less present in thinning hair follicles and this decrease might contribute to common hair loss in men.

Lichen Planopilaris and Frontal Fibrosing Alopecia may help us understand hair follicle stem cell disorders and suggest new treatments.

Smart biomaterials that guide tissue repair are key for future medical treatments.

Wnt signaling is crucial for skin and hair development and its disruption can cause skin tumors.

Wnt signaling is crucial for skin wound healing and reducing scars.

The document concludes that understanding hair and feather regeneration can help develop new regenerative medicine strategies.

Hair follicles can help wounds heal faster and this knowledge could be used to treat chronic skin ulcers, with a potential use of a special stem cell hydrogel to enhance healing.

Stress in mice delays hair growth and treatments blocking substance P can partly reverse this effect.

The skin and thymus develop similarly to protect and support immunity.

The conclusion is that skin and hair patterns are formed by a mix of cell activities, molecular signals, and environmental factors.

Lipocalin-Type Prostaglandin D2 Synthase (L-PGDS) is a protein that plays many roles in the body, including sleep regulation, pain management, food intake, and protection against harmful substances. It also affects fat metabolism, glucose intolerance, cell maturation, and is involved in various diseases like diabetes, cancer, and arthritis. It can influence sex organ development and embryonic cell differentiation, and its levels can be used as a diagnostic marker for certain conditions.

Mesenchymal stem cell therapy may help treat alopecia areata by promoting hair growth and reducing inflammation.

Eyelid cells share signaling components but differ in pathway activity.

Targeting the protein Caveolin-1 might help treat a type of scarring hair loss called Frontal Fibrosing Alopecia.

TRPV4 helps cells repair tissue and reduce scarring by controlling calcium levels.

The new method using gene-modified stem cells and a 3D printed scaffold improved skin repair in mice.

Understanding skin structure and development helps diagnose and treat skin disorders.

The document concludes that pig iPSCs show promise for transplant therapies and the field is advancing in controlling cell behavior for biology and medicine.

Substances from fat-derived stem cells can promote hair growth and counteract hormone-related hair loss by activating a key hair growth pathway.