Transplanted Hair Follicle Mesenchymal Stem Cells Alleviated Small Intestinal Ischemia–Reperfusion Injury via Intrinsic and Paracrine Mechanisms in a Rat Model

    October 2022 in “ Frontiers in Cell and Developmental Biology ”
    Yang Gao, Yukui Zhang, Xueyu Cang, Hongliang Chen, Yuzhu Di, Jihan Qi, Huimin Cai, Kunpeng Luo, Shizhu Jin
    TLDR Transplanted hair follicle stem cells can heal damaged rat intestines.
    The study demonstrates that transplanted hair follicle mesenchymal stem cells (HFMSCs) can effectively treat small intestinal ischemia-reperfusion (IR) injury in rats. HFMSCs home to the damaged site, proliferate, and differentiate into intestinal stem cells, promoting tissue repair and regeneration. They enhance angiogenesis, reduce apoptosis, and mitigate oxidative stress, thereby improving intestinal morphology and function. The findings suggest HFMSCs as a promising therapeutic approach for intestinal IR injury through intrinsic and paracrine mechanisms.
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