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The skin is the largest organ, protecting the body, regulating temperature, and producing hormones.

The French Endocrine Society suggests diagnosing PCOS with two of three signs, recommends lifestyle changes and clomiphene for treatment, and calls for more research on certain treatments and tests.

Metformin and rosiglitazone both improved insulin use and hormonal symptoms in women with PCOS.

Some women with PCOS have CYP21 mutations and IRS1 variants, but these genetic factors are not major contributors to PCOS.

Certain genetic variations in the SHBG gene are linked to an increased or decreased risk of PCOS in Mediterranean women.

Insulin-lowering medications show promise for PCOS symptoms but can't be the main treatment yet due to limited long-term research.

Blocking CRF-R1 can reduce alcohol intake in stressed mice.

Weight loss and metformin don't significantly change vaspin levels in women with PCOS.

Women with only irregular periods or excess hair have a better hormone profile than those with full PCOS, but both groups are similar, indicating a need for better PCOS diagnosis methods.

The document suggests that clinical trials for PCOS should focus on meaningful primary outcomes like live birth rates, rather than less reliable surrogate markers.

Natural molecules like inositols, resveratrol, vitamins, and omega-3 fatty acids may help manage Polycystic Ovary Syndrome (PCOS), but their effects vary and need more exploration.

The skin is a complex barrier that protects the body, regulates temperature, and helps with immune responses.

Women with PCOS are more likely to have fatty liver disease and worse metabolic health.

Metformin should be used for PCOS mainly in those with glucose intolerance, and has limited benefits for infertility or hirsutism.

Women with PCOS have a higher risk of diabetes, heart problems, certain cancers, and mental health issues, but early treatment can help manage these risks.

New treatments for PCOS show promise, but no current medication treats all aspects of the condition.

Menstrual disorders are common in adolescents and can be influenced by weight, activity, and health issues, requiring careful evaluation and more research for effective treatment.

Metformin improves menstrual cycles and hormone levels in women with PCOS, mostly within the first 6 months.

High afamin levels are linked to metabolic syndrome and may predict its development in women with insulin resistance.

Over half of the adult women with acne in the study had higher than normal levels of male hormones, especially DHEA.

Doctors should know how to diagnose and treat PCOS, which often involves checking for high male hormone levels and using medications to manage symptoms.

Type I interferons play a key role in the development of various skin diseases.

People with psoriasis are more likely to have Metabolic Syndrome than those without psoriasis.

Brazilian women with PCOS and both menstrual irregularity and high male hormone levels have a higher chance of having metabolic syndrome.

Insulin-sensitizing drugs like metformin can help with ovulation, weight loss, and lower testosterone in some women with PCOS.

Curcumin may improve blood sugar levels and cholesterol in people with PCOS, but more research is needed.

The study suggests that being overweight or obese, not PCOS itself, is strongly linked to insulin resistance.

New treatments for PCOS focus on insulin resistance and reducing testosterone levels, along with traditional hormone therapies.

Young women with PCOS have a higher risk of high blood pressure and metabolic syndrome, but these risks may decrease after age 40.

Men with common hair loss may have a higher risk of heart disease and diabetes, and should be checked for these conditions.