Polycystic Ovary Syndrome (PCOS): French Endocrine Society Recommendations for Diagnosis and Management

    January 2010 in “ Annales D Endocrinologie ”
    Didier Dewailly, S. Hieronimus, P. Mirakian, Jean-Noël Hugues
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    TLDR The French Endocrine Society suggests diagnosing PCOS with two of three signs, recommends lifestyle changes and clomiphene for treatment, and calls for more research on certain treatments and tests.
    In 2010, the French Endocrine Society provided recommendations for diagnosing and managing Polycystic Ovary Syndrome (PCOS), endorsing the Rotterdam classification which requires two out of three criteria: menstrual irregularities, hyperandrogenism, and polycystic ovaries on ultrasound. The document advised against using the Ferriman-Gallway score for hirsutism diagnosis and deemed routine screening for elevated plasma LH or GnRH testing unnecessary. It emphasized systematic screening for metabolic abnormalities and recommended an oral glucose tolerance test for obese women with normal fasting serum glucose. Clomiphene citrate was recommended as the first-line therapy for ovulation induction, with lifestyle modifications advised for patients with a BMI over 30. The document also noted that a 5% reduction in baseline weight could improve pregnancy chances and that the combination of metformin with clomiphene citrate was not proven effective for all women with PCOS. Further research was suggested for the efficacy and safety of aromatase inhibitors and the value of OGTT in non-obese women with PCOS.
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