Polycystic Ovarian Syndrome: Long-Term Health Consequences

    May 2017 in “ Seminars in Reproductive Medicine ”
    Temeka Zore, Nikhil Joshi, Daria Lizneva, Ricardo Azziz
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    TLDR Women with PCOS have a higher risk of diabetes, heart problems, certain cancers, and mental health issues, but early treatment can help manage these risks.
    The document from May 1, 2017, reviews the long-term health consequences of Polycystic Ovarian Syndrome (PCOS), a common endocrinopathy in women. It emphasizes the increased risk of metabolic disorders such as type 2 diabetes mellitus, metabolic syndrome, and nonalcoholic fatty liver disease, as well as cardiovascular issues, certain types of cancer, and mental health disorders like depression and anxiety in women with PCOS. The review also discusses the impact of different PCOS phenotypes and obesity on these risks. It suggests that early diagnosis and treatment, including lifestyle interventions and medications like metformin, could mitigate these long-term morbidities. The economic burden of PCOS is significant, with substantial costs associated with its management. The document concludes that while the etiology of PCOS is not fully understood, appropriate management strategies can help in preventing the progression or severity of the condition.
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