January 2019 in “Can Tho University Journal of Science” This study reported that applying a nanosilica-bromelain-curcumin complex improved wound healing and hair regrowth in mice with second-degree burns compared to no treatment.
28 citations
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January 2019 in “IRAQI JOURNAL OF AGRICULTURAL SCIENCES” In this study, researchers found that silica nanoparticles synthesized using cold plasma showed a higher biofilm inhibition effect on Staphylococcus aureus and Escherichia coli compared to those made with a magnetic stirrer.
January 2025 in “New Journal of Chemistry” In this study, researchers developed hollow mesoporous organosilica nanoparticles and confirmed their synthesis using IR spectroscopy, then evaluated the nanoparticles for endocytosis and biocompatibility, although specific results of these tests are not reported in the abstract.
12 citations
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June 2020 in “Crystals” This study presents a modified method for synthesizing ~1 nm zinc oxide nanoparticles within the pores of SBA-11, maintaining the mesoporous structure without requiring alcohol reflux or basic solution reaction steps.
January 2026 in “Microsystems & Nanoengineering” This study analyzed 853 articles to reveal that research on silica-based nanobiomaterials in regenerative medicine has rapidly increased, with distinct regional differences in impact and emerging focus areas in drug delivery and wound healing.
January 2013 in “IRIS UNIMORE (University of Modena and Reggio Emilia)” This study found that silica nanoparticles penetrate the outer stratum corneum of human skin, with surface hydrophobization potentially enhancing this penetration.
December 2024 in “Chinese Chemical Letters” This study found that using hollow mesoporous silica nanoparticles as carriers in a topical finasteride formulation significantly enhanced drug retention and hair regrowth in an AGA mouse model, suggesting a promising approach for treating androgenetic alopecia with reduced side effects.
15 citations
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April 2021 in “International Journal of Pharmaceutics” This study found that smaller mesoporous silica particles (400-600 nm) accumulated in skin furrows, suggesting their potential as carriers for enhancing the delivery of topical medications like metronidazole.
16 citations
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August 2014 in “Colloids and surfaces. B, Biointerfaces” This study found that hydrophobic lipid-coated silica nanoparticles penetrated deeper into human stratum corneum compared to their hydrophilic counterparts, highlighting the influence of surface polarity on skin penetration.
7 citations
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December 2024 in “International Journal of Pharmaceutics” In this study, researchers developed a new method for producing dissolving microneedle array patches containing mesoporous silica nanoparticles, successfully confirming nanoparticle deposition and release in both ex vivo and in vivo models.
2 citations
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February 2016 in “Journal of sol-gel science and technology” This study found that 3-aminopropyltriethoxysilane penetrates hair fibers and improves the mechanical resistance of dry hair, addressing the needs for increased body in fine hair.
8 citations
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January 2021 in “Pharmaceutics” This study found that using nanoporous silica entrapped lipid-drug complexes enhanced the solubility and bioavailability of dutasteride in beagle dogs.
44 citations
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November 2012 in “International journal of nanomedicine” This study found that silicone oil-in-water nanoemulsions using nonionic surfactants can enhance silicone oil absorption on hair, suggesting a promising method for hair care applications.
23 citations
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October 2012 in “ChemistryOpen” This study found that capped mesoporous silica nanoparticles conjugated with antibodies selectively released a dye when exposed to finasteride, with low detection limits and stable performance even after storage.
18 citations
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January 2016 in “Elsevier eBooks” This chapter reviews nanotechnology in cosmetics, detailing various formulations, performance assessment methods, and evolving regulations, while discussing safety, stability, and effectiveness concerns; it reports no new experimental results.
August 2026 in “Fabad Journal of Pharmaceutical Sciences” This study developed a Neusilin® US2-based solid self-nanoemulsifying drug delivery system for finasteride that showed improved stability and drug delivery, with complete dissolution comparable to standard Propecia® tablets.
September 2023 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that dissolving microneedle array patches containing mesoporous silica nanoparticles can deliver antigen-loaded nanoparticles into mice effectively, inducing strong immune responses similar to traditional subcutaneous injection.
January 2026 in “BioNanoScience” January 2026 in “PubMed Central” This article reviews self-assembled nanoparticles, highlighting their promising role in drug delivery systems but noting the need for further research on stability and large-scale industrial application; it reports no new clinical findings.
16 citations
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November 2020 in “International journal of pharmaceutics” This study found that PEGylation of nanoparticles enhances their penetration into hair follicles, with higher molecular weight PEG resulting in deeper follicular delivery.
45 citations
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June 2016 in “Anais brasileiros de dermatologia/Anais Brasileiros de Dermatologia” This review evaluates the scientific literature on silicon supplements, noting that orthosilicic acid shows higher bioavailability, but emphasizes the need for further clinical studies on safety and efficacy.
1 citations
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December 2022 in “Applied Sciences” 2 citations
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May 2025 in “Skin Appendage Disorders” This review highlights the benefits and controversies of silicones in hair care, emphasizing their ability to improve hair texture and moisture retention while addressing environmental concerns and product buildup.
December 2023 in “International Journal of Pharmaceutics” This study developed innovative silica/natural polysaccharide hybrid nanoparticles encapsulating plant-derived 5-alpha-reductase inhibitors, reporting effective controlled release at hair follicle pH and lower cytotoxicity, suggesting a promising delivery system for antiandrogenic treatments.
March 2019 in “SLAS TECHNOLOGY” This study found that MSN-ceria nanomaterial accelerates cutaneous wound healing in rat models by reducing ROS levels and promoting collagen deposition, leading to improved tissue regeneration without significant scarring.
January 2019 in “Springer eBooks” PLGA nanospheres in cosmetics improve skin and hair treatment effectiveness.
In this clinical trial, the researchers observed that a biotin and silica supplement reduced hair fall, increased hair growth rate, and improved skin elasticity, hydration, and nail quality over 90 days without adverse effects.
4 citations
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January 2010 in “Laboratory Animal Research” This study found that Na2SiO3 accelerated hair regrowth in mice, indicating potential for treating alopecia, though it did not significantly alter enzyme activity compared to distilled water.
December 2013 in “Biomedical and biopharmaceutical research” This review discusses technological advances in liposome systems for drug delivery and reports no new clinical results; it highlights the clinical acceptance and market presence of liposomal products.
6 citations
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April 2022 in “Advanced Pharmaceutical Bulletin” This study found that cefazolin-loaded silica nanoparticles embedded in polycaprolactone nanofibers successfully inhibited Staphylococcus aureus growth while maintaining stem cell viability, suggesting their potential use in wound healing.