Cefazolin-Loaded Double-Shelled Hollow Mesoporous Silica Nanoparticles/Polycaprolactone Nanofiber Composites: A Delivery Vehicle for Regenerative Purposes

The study explored the use of double-shelled hollow mesoporous silica nanoparticles (DSH-MSNs) loaded with cefazolin and incorporated into polycaprolactone (PCL) nanofibers as a drug delivery system for regenerative purposes. The DSH-MSNs demonstrated a high cefazolin loading capacity of 51% and provided a slow release of the antibiotic, effectively inhibiting the growth of Staphylococcus aureus. The nanofibers showed high biocompatibility with human adipose-derived stem cells, promoting cell viability and up-regulating keratinocyte-related differentiation genes. These findings suggested that Cef*DSH-MSNs/PCL composites could be a promising strategy for wound healing and regenerative applications.