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This study reviews various skin models and methodologies used to assess the follicular penetration of nanoparticle-based drugs, highlighting inconsistencies that complicate comparisons and aims to establish more uniform protocols for clearer study outcomes.

This study demonstrated that a finasteride-loaded proniosome significantly enhanced transfollicular delivery and hair growth in mice without causing skin irritation, with effects comparable to a 2% minoxidil solution.

This study highlights IGF-1's role in promoting hair follicle proliferation, vascularization, and growth, suggesting its potential as a treatment target for hair loss disorders like androgenetic alopecia, though more research on delivery methods and long-term effects is needed.

This article discusses various vitamin deficiencies and their neurological implications without providing new clinical results; it serves as an informative chapter on nutrient-related neurological conditions.

This study observed that dissolving microneedles made from PVP-K90 and HPMC E50, incorporating Oryza sativa L. extract complex, showed enhanced transfollicular skin penetration and maintained safety for keratinocytes, with the P25H5 formulation demonstrating faster dissolution and greater effectiveness.

This study found that specific human hair keratins are differentially expressed in the hair follicle, suggesting a shared pathway of epithelial differentiation between hair cortex and nail plate cells.

This study found that trichocytic cytokeratins, typically found in hair, are also present in nails, filiform papillae of the tongue, and the epithelial reticulum of the thymus.

This study describes previously unknown immune characteristics of the normal human nail, highlighting its similarities to the hair follicle immune system and suggesting an immune privilege in the proximal nail matrix that both provides autoimmunity protection and presents infection susceptibility.

This review discusses the classification, pathogenesis, and management of skin, hair, nail, and mucosal changes due to EGFR inhibitors, emphasizing the importance of informing patients to improve therapy compliance.

This study found that keratin expression patterns vary within nail unit structures, with the nail matrix uniquely expressing the acidic hair-type keratin Ha1.

This study found that while most mice lacking MK6a and MK6b genes died from tongue epithelium disintegration, about 25% survived and showed no hair or nail defects due to a newly discovered MK6hf gene.

This review examines the existing research on pathologic hairpulling, skin picking, and nail biting, suggesting these behaviors are underrecognized and may benefit from a unified diagnostic categorization; it reports no new clinical findings.

This study found that videodermoscopy can help diagnose nailbed psoriasis by revealing distinctive hyponychial capillary patterns, which correlated with disease severity and response to treatment.

This study found that loss-of-function mutations in the HOXC13 gene cause autosomal-recessive pure hair and nail ectodermal dysplasia, emphasizing its role in hair and nail development.

This study found that keratin films made from human hair can potentially substitute for human nail plates in drug permeability studies, but they show higher sensitivity to penetration enhancers compared to bovine hooves.

This study suggests a regulatory model where HOXC13 activates Foxn1, affecting hair and nail differentiation, supported by similarities in Hoxc13(tm1Mrc) and Foxn1(nu) mice phenotypes and gene expression patterns.

This study concluded that the ClinRO and PRO measures, along with their photoguides, offer clear and meaningful assessments for patients with alopecia areata concerning eyebrow, eyelash, and nail appearance, as well as eye irritation.

This study found that the mouse nail unit structurally resembles the human nail unit, indicating it could be useful for researching nail diseases and biology.

This study found that terbinafine HCl nail solutions with or without DDAIP HCl significantly outperformed ciclopirox nail lacquer in treating guinea pig dermatophytosis, suggesting potential effectiveness for human nail infections.

This review explores nail changes associated with alopecia areata, noting their prevalence and impact on appearance and function, but reports no new clinical findings; the authors call for larger controlled trials.

In this study, researchers identified two distinct homozygous mutations in the KRT85 gene among consanguineous Pakistani families with pure hair and nail ectodermal dysplasia, highlighting variations in severity and potential impacts on the K85 protein function.

This study observed that PAI-2 is consistently expressed in differentiating cells of murine hair and nail, suggesting it may function as a marker of differentiation and possibly protect against premature cell death.

Tofacitinib citrate improved nail dystrophy and pain in patients with alopecia universalis without causing side effects.

In this study, researchers found that targeted therapies for metastatic melanoma often cause hair and nail side effects, with hair changes more common in patients treated with BRAF inhibitors like vemurafenib.

This study found that a newly identified gene, mK17n, may explain the lack of nail issues in mK17 null mice by compensating for mK17's function in the nail bed.

This study identified a homozygous frameshift mutation in the HOXC13 gene associated with pure hair and nail ectodermal dysplasia in a consanguineous Syrian family, suggesting crucial roles for HOXC13 in hair and nail development.

This study describes how shotgun proteomics can identify over 300 proteins in hair shafts, potentially allowing for the diagnosis of diseases through noninvasive human proteome sampling.

This study reports that the Pfizer-BioNTech COVID-19 vaccine showed 52% protection against COVID-19 after the first dose and 95% after the second in phase 3 trials.

This case report highlights trichotillomania's distinguishing "tonsure pattern" and nail-biting, emphasizing the need to differentiate it from other hair loss types due to differing treatments.

This study indicates that nail-matrical fibroblasts can induce hard keratin expression in non-nail-matrical keratinocytes, suggesting potential for using non-nail-matrical epidermal grafts to treat nail injuries.