Determination of the Efficacy of Terbinafine Hydrochloride Nail Solution in the Topical Treatment of Dermatophytosis in a Guinea Pig Model
May 2008
in “
Mycoses
”
New to Ciclopirox? There is a guide in the encyclopedia. Read the guide → Studysummary This study found that terbinafine HCl nail solutions with or without DDAIP HCl significantly outperformed ciclopirox nail lacquer in treating guinea pig dermatophytosis, suggesting potential effectiveness for human nail infections. Our plain-language summary of this paper — not a Tressless recommendation.
The study evaluated the efficacy of terbinafine HCl nail solutions (TNS) in treating dermatophytosis using a guinea pig model. The formulations included a nail penetration enhancer, DDAIP HCl, and were compared to ciclopirox nail lacquer, the only FDA-approved topical treatment for onychomycosis at the time. The study involved 11 groups of guinea pigs, each with 5 animals, treated with various concentrations of TNS and DDAIP HCl. Results showed that TNS, both with and without DDAIP HCl, achieved 100% mycological efficacy, significantly outperforming ciclopirox. The addition of 0.5% DDAIP HCl to 5% and 10% TNS notably improved clinical efficacy. The findings suggested that TNS formulations, especially those enhanced with DDAIP HCl, were highly effective and warranted further clinical trials for treating dermatophytosis and onychomycosis.
