Determination of the Efficacy of Terbinafine Hydrochloride Nail Solution in the Topical Treatment of Dermatophytosis in a Guinea Pig Model

The study evaluated the efficacy of terbinafine HCl nail solutions (TNS) with and without the nail penetration enhancer DDAIP HCl in treating dermatophytosis in guinea pigs. The study involved 11 groups of guinea pigs, each with 5 animals, infected with Trichophyton mentagrophytes. Results showed that TNS formulations, particularly those with 5% and 10% terbinafine HCl combined with 0.5% DDAIP HCl, achieved 100% mycological efficacy and significantly improved clinical outcomes compared to the 8% ciclopirox nail lacquer. The addition of DDAIP HCl enhanced the efficacy of TNS, suggesting that these formulations were superior to the existing FDA-approved treatment. The study concluded that clinical trials for TNS in treating dermatophytosis and onychomycosis were warranted.