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research The Novel Excipient, Dodecyl-2-N, N-dimethylaminopropionate Hydrochloride (DDAIP-HCl) Improves the Flux of Minoxidil in Human Skin

2 citations , January 2012 in “Hair therapy & transplantation”

This study observed that DDAIP-HCl enhanced the permeation of minoxidil through human cadaver skin, suggesting potential for improved treatment efficacy in male pattern hair loss.

research Determination of the efficacy of terbinafine hydrochloride nail solution in the topical treatment of dermatophytosis in a guinea pig model

51 citations , May 2008 in “Mycoses”

This study found that terbinafine HCl nail solutions with or without DDAIP HCl significantly outperformed ciclopirox nail lacquer in treating guinea pig dermatophytosis, suggesting potential effectiveness for human nail infections.

research Minoxidil Induction of VEGF Is Mediated by Inhibition of HIF-Prolyl Hydroxylase

22 citations , December 2017 in “International Journal of Molecular Sciences”

This study found that millimolar concentrations of minoxidil in the skin induced VEGF production through HIF-1 stabilization by inhibiting PHD-2, implying a molecular mechanism for hair growth promotion.