Induction of Hard Keratin Expression in Non-Nail-Matrical Keratinocytes by Nail-Matrical Fibroblasts Through Epithelial-Mesenchymal Interactions

    January 2003 in “ Plastic & Reconstructive Surgery ”
    Mutsumi Okazaki, Kotaro Yoshimura, Hiroshi Fujiwara, Yasutoshi Suzuki, Kiyonori Harii
    TLDR Nail-matrical fibroblasts can make non-nail cells produce hard keratin, useful for nail repair.
    The study investigated whether nail-matrical fibroblasts could induce hard keratin expression in non-nail-matrical keratinocytes. Skin equivalents were created by coculturing ventral keratinocytes with either ventral fibroblasts or nail-matrical fibroblasts, and nail-matrical keratinocytes with ventral fibroblasts. Results showed that hard keratin was expressed in groups where nail-matrical fibroblasts were present, indicating that these fibroblasts could induce hard keratin expression in non-nail-matrical keratinocytes. This suggested potential applications for non-nail-matrical epidermal grafts in treating nail injuries and reconstructing lost nails using tissue-engineered nail equivalents.
    Discuss this study in the Community →

    Research cited in this study

    3 / 3 results

    Related Community Posts Join

    6 / 1000+ results

      community Comprehensive Microneedling Guide

      in Microneedling  294 upvotes 3 years ago
      Microneedling for hair restoration involves daily use of a 0.3 mm device and weekly use of a 0.5 mm device. Combining microneedling with Minoxidil can enhance hair growth.

      community Nice product I discovered, thought I would share.

      in Treatment  456 upvotes 8 months ago
      A product that makes hair look thicker and healthier without promoting regrowth. Discussions include treatments like minoxidil, finasteride, red light therapy, and a serum with caffeine and peptides, with mixed effectiveness opinions.

      community Finally seeing some progress 24M

      in Progress Pictures  24 upvotes 1 month ago
      A 24-year-old male experienced hair loss and side effects from oral finasteride and minoxidil, but saw progress with a topical solution of minoxidil and finasteride, alongside dermastamping and vitamin supplements. He uses 2% Nizoral and keratin shampoo for hair care.

      community Why does my hair look so much less bald after shower vs upon waking up?

      in Chat  7 upvotes 2 years ago
      The conversation discusses the user's observation of their hair appearing less bald after showering compared to when they wake up. They use a biotin and keratin conditioner and ketoconazole twice a week, while others suggest the difference in appearance could be due to oil build-up or the hair's response to water.

      community Results of Procyanidin B2 in clinical studies

      in Treatment  11 upvotes 5 years ago
      Procyanidin B2, a compound derived from Annurca apples, as a potential treatment for pattern hair loss. Several clinical studies were mentioned, which found that procyanidin B2 could increase hair growth, density, and keratin content. Other treatments such as Minoxidil, Finasteride, and RU58841 were not discussed.

      community Dec 2024 vs now (min + fin/dut)

      in Progress Pictures  27 upvotes 1 month ago
      The user experienced hair thickening and reduced shedding using minoxidil, finasteride, and dutasteride, with a switch from finasteride to dutasteride due to ineffectiveness. They also use a saw palmetto shampoo and take vitamin D3 supplements, while considering potential underlying causes like vitamin deficiencies and hard water buildup.

    Related Research

    1 / 1 results