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Accurate quantitative bioanalysis using LC-MS/MS is challenging due to matrix effects, but using internal standards and new methods like in-sample calibration could improve results.

Hair elemental analysis could be useful for health and exposure assessment but requires more standardization and research.

The method effectively identifies banned substances in hair loss and skin disease cosmetics.

Hair proteins have weak spots in their α-helical segments.

Method measures latanoprost and minoxidil in skin accurately and precisely.

The method effectively detects banned substances in urine for sports antidoping.

A new method accurately detects bisphenols and parabens in human hair.

Blocking the Wnt pathway could lead to new treatments for cancer and tissue repair but requires careful development to avoid side effects.

The method accurately measures 19 steroid hormones in human blood and urine using a small sample and is suitable for large-scale monitoring.

Certain microRNAs are linked to various skin diseases and could be used to diagnose and treat these conditions.

Matrix effects in LC-MS can be managed but not completely avoided.

Method detects finasteride in plasma at very low concentrations.

The lentiviral array can monitor and predict gene activity during stem cell differentiation.

Paclitaxel is an effective cancer drug with side effects and potential new uses beyond cancer.

Autophagy is crucial for normal sebaceous gland function and sebum composition.

Activating Notch signaling can kill basal cell carcinoma cells.

Researchers found that certain lipids, especially vitamin D3, are lower in prematurely grey hair than in pigmented hair.

The research suggests that autophagy-related genes might play a role in causing alopecia areata.

Teriflunomide helps reduce multiple sclerosis symptoms and is safe for most patients.

CXXC5 can both suppress and promote cancer, making it a complex target for treatment.

The document concludes that using LC-MS/MS for measuring androgens is more accurate than older methods, but it needs careful validation and standardized references to be most effective.

NF-κB signaling is crucial in many diseases and can be targeted for new treatments.

Acne treatment with isotretinoin increases the presence of p53, a protein, in skin and oil glands, which may help reduce acne severity.

Forensic hair analysis for drugs is now more reliable and accurate.

The conclusion is that standardizing testosterone measurement methods is essential for better diagnosis accuracy in women.

New therapies are being developed that target integrin pathways to treat various diseases.

The method reliably profiles eicosanoids and shows epitestosterone reduces their levels, similar to common anti-inflammatory drugs.

A boy's growth and immune problems were caused by a new mutation in the STAT5B gene.

Researchers developed a method to detect hormone-blocking drugs in wastewater and found them in Beijing's sewage, suggesting they can survive sewage treatment.

Early anti-aging hair treatments should focus on anti-inflammatory agents and promoting healthy hair growth cycles.