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This study suggests that Notch1 acts as a key signal in skin epithelium, promoting immune cell recruitment and aiding in normal skin repair after damage.

In this rat study, bone marrow mesenchymal stem cell therapy reduced mortality and intestinal damage in acute liver failure by alleviating endotoxemia.

This study found that the novel IPC analog SIG-1451 may inhibit inflammatory cytokine release in cell-based assays relevant to allergic dermatitis.

This study demonstrated that supplementing aged mice with pro-IGF-II improved muscle regeneration by enhancing satellite cell proliferation and reducing adipogenesis, suggesting potential benefits for treating muscle injuries in elderly individuals.

This study highlights the role of innate immunity and purinergic signaling in regulating hematopoiesis and hematopoietic stem/progenitor cell specification. The researchers observed that these ancient pathways operate both paracrinally and autocrinally within HSPCs, maintaining their developmental function throughout evolution.

This study observed that long-term laser hair removal in women may alter hair follicle structures and stem cell interactions, with dermal fibrosis potentially influencing hair regrowth prevention.

The conditions alopecia areata, primary sclerosing cholangitis, and ulcerative colitis may be linked by shared autoimmune and cell death mechanisms.

In this study, the novel isoprenylcysteine analog SIG-1451 was shown to inhibit pro-inflammatory cytokine release in various cell-based assays relevant to allergic dermatitis, acting on targets such as IL-4 and IL-6 with potential anti-inflammatory benefits.

In this study, 13-cis-5S*,8S*-epidioxy-5,8-dihydroretinoic acid was found to be significantly more cytotoxic to cancer cell lines than other retinoic acid analogs evaluated.

This study provides evidence that innate lymphoid cells-type 1 can induce alopecia areata in human hair follicles, challenging the view that it is solely a CD8+ T cell-driven autoimmune disease.

This study found that obesity in women may impair endometrial stromal function and contribute to reproductive complications, possibly due to metabolic influences rather than immune cell differences.

This study, using multimodal profiling in mice, found that various tissues contain unique γδ T cell subsets adapted to their environment, revealing their functional diversity, lineage relationships, and similarities to CD8+ tissue-resident memory T cells.

This study developed an AI-driven method for classifying cells in Follicular Lymphoma cases, achieving a 63% F1-score, precision, and recall in distinguishing centroblasts from other cell types using whole slide images at x20 resolution.

In this study, researchers at the Laboratory of Regenerative Medicine WUM are exploring the long-term effects of SARS-CoV-19 infection, focusing on stem cell mobilization and engraftment processes, and utilizing advanced diagnostic techniques to develop algorithms for rare disease classification, including amyloidosis.

This study found that activating Toll-like receptor 3 signaling in periodontal ligament stem cells may enhance their immunomodulatory properties, suggesting potential implications for future stem cell therapy applications.

This study characterized a novel form of mural folliculitis in dogs, resembling human pseudopelade, marked by persistent alopecia, lymphocyte infiltration, and severe follicular atrophy without effective treatment response.

This study investigated the impact of the JAK inhibitor ruxolitinib on APS-1 patients, reporting that treatment decreased excessive T-cell-derived interferon-γ, normalized inflammatory markers, and led to remission of several autoimmune symptoms without serious adverse effects.

This study found that allergen treatment in alopecia areata mice appeared to alter leukocyte subset distribution and impaired dendritic cell migration, which may affect T-cell activation and hair follicle recovery.

This review discusses immune privilege in anagen hair follicles and its collapse in alopecia areata, emphasizing the importance of restoring this function for effective management and disease relapse prevention.

D-chiral biomaterial scaffolds enhance tissue and hair regeneration by activating the body's immune system.

This manuscript reviews the latest understanding of alopecia areata's pathogenesis, highlighting the roles of genetic, immunological, and environmental factors, with a focus on immune responses involving IFN-γ and cytotoxic CD8+ T-cells as key contributors to hair follicle inflammation and function disruption without follicle destruction.

This review discusses how targeting apoptosis pathways in hair and skin cells can inform the development of novel therapies, but it reports no clinical findings.

This review discusses the potential of mesenchymal stem/stromal cells and their exosomes in promoting wound healing and skin regeneration, but reports no new experimental results.

Androgenetic alopecia treatments focus on reducing hair loss by targeting hormones, with new therapies showing promise but needing more research.

This article offers a viewpoint on hidradenitis suppurativa pathogenesis, suggesting that impaired Notch signalling from γ-secretase mutations may drive inflammation and link the condition to other Th17-driven diseases.

This review discusses the challenges of skin graft acceptance and examines current strategies and alternatives for full-thickness skin replacement and repair, noting that immunological rejection remains a significant hurdle.

This study found that certain T cell-associated genes were upregulated in dogs with Vogt-Koyanagi-Harada syndrome and vitiligo, suggesting a shared immunopathogenesis with humans.

This study found that combining adipose-derived mesenchymal stromal cells with meglumine antimoniate reduced lesion size and parasite load in mice with leishmaniasis, suggesting potential for improved treatment.

This review discusses various types of stem cells used in regenerative medicine, including adult stem cells and induced pluripotent stem cells (iPSCs), and evaluates them based on their embryonic tissue origins to explore new therapeutic approaches.

This review summarizes research on scar formation and inhibition mechanisms, discussing emerging therapies like gene therapy and stem cell treatments, but notes ongoing challenges for clinical application, including treatment personalization and outcome sustainability.