Pro-Insulin-Like Growth Factor-II Ameliorates Age-Related Inefficient Regenerative Response by Orchestrating Self-Reinforcement Mechanism of Muscle Regeneration

The document presents a study on the effects of pro-Insulin-Like Growth Factor-II (pro-IGF-II) on muscle regeneration in aged mice. The study found that the inefficiency in muscle regeneration with age is due to extrinsic changes in the muscle environment rather than intrinsic changes in satellite cells. Although the number of satellite cells decreased with age, the remaining cells retained their capacity for muscle regeneration. The study identified a decline in pro-IGF-II levels in aged mice, which contributed to the regenerative inefficiency. By supplementing pro-IGF-II, the study observed improved muscle regeneration in aged mice, characterized by enhanced satellite cell proliferation, increased angiogenesis, and reduced adipogenic differentiation of PDGFRα* mesenchymal progenitors. The study concluded that pro-IGF-II supplementation could be a potential therapeutic strategy for treating muscle injuries in the elderly. However, the number of mice used in the study was not specified in the summary.