1 citations
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April 2022 in “Applied sciences” This study reports the development of a microemulsion using Momordica charantia extract, which demonstrated strong antioxidant and 5α-reductase inhibitory activity, potentially aiding hair loss management. The microemulsion was stable over 12 weeks, suggesting its future potential for cosmetic or pharmacological applications.
January 2018 in “Journal of analytical, bioanalytical and separation techniques” 1 citations
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January 2017 in “International Journal of Trichology” This case report describes a 6-year-old girl diagnosed with monilethrix, experiencing hair fragility and loss after a fever, and showing improvement in hair density following treatment, despite persistent symptoms.
21 citations
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September 2001 in “Graefes Archive for Clinical and Experimental Ophthalmology” This study found that minoxidil inhibited lens epithelial cell migration, proliferation, and collagen secretion in vitro, suggesting it may help prevent postoperative capsular opacification.
3 citations
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October 2013 This study found that microemulsion and microemulsion-based hydrogels may offer a more effective and sustained topical delivery method for minoxidil compared to conventional solutions for hair loss treatment.
January 2026 in “Biocell” This review discusses the potential of gut microbiota-derived exosomes as drug delivery systems and reports no new clinical results; the authors highlight their promise for precision medicine.
4 citations
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November 1999 in “PubMed” This article presents five family cases of monilethrix and reports that neither vitamins nor desquamative ointments are effective treatments, although symptoms may spontaneously regress over time.
This case report highlights a rare instance of minoxidil-induced pleuro-pericardial effusion with tamponade in a patient with end-stage renal disease on hemodialysis, which improved following pericardiocentesis and discontinuation of the drug.
October 2019 in “DOAJ (DOAJ: Directory of Open Access Journals)” In this study, N-MXD (minoxidil nanoparticles) was shown to deliver more drug into hair bulbs and enhance IGF-1 and VEGF levels more effectively than commercial formulations, resulting in higher therapeutic efficiency for hair growth in C57BL/6 mice.
November 2023 in “Circulation” In this case report, a 59-year-old man experienced recurrent pericardial effusion linked to minoxidil, with serologic indications of drug-induced lupus erythematosus, underscoring the need for clinicians to consider this rare complication of widespread minoxidil use.
4 citations
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January 2009 in “International journal of trichology” Minoxidil topical foam is a better, less irritating treatment for hair loss.
5 citations
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February 2013 in “Journal of Liquid Chromatography & Related Technologies” This study developed and validated a micellar electrokinetic chromatography method to determine finasteride stability, finding that the drug degrades under acidic, basic, and oxidative stress conditions.
118 citations
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August 2010 in “Developmental Cell” This study found that the protein MIM is crucial for maintaining cilia and Sonic hedgehog signaling in mesenchymal cells by counteracting Src-mediated phosphorylation of Cortactin, impacting hair follicle formation.
33 citations
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November 1994 in “Archives of Biochemistry and Biophysics” January 2004 in “Drug Development and Industrial Pharmacy” This study explored the solubility and crystal structure of GI197111X, a 5-alpha reductase inhibitor for androgenetic alopecia, finding its solubility in Capmul MCM suitable for a soft gel dosage form.
November 2025 in “Repositorio Comunidad Politecnico Grancolombiano” This research focuses on Milagros's strategy to internationalize by exporting their intensive repair hair mask to Mexico, France, and the United States, examining each market's potential and challenges in the global hair care sector.
1 citations
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October 2017 in “Food Additives & Contaminants: Part A” This study identified a new minoxidil analogue called triaminodil in an illegal hair-growth supplement, but no data on its chemical, toxicological, or pharmacological properties are available yet.
38 citations
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June 2005 in “Matrix Biology” Minoxidil affects collagen-related genes, potentially helping treat fibrosis.
18 citations
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July 2009 in “Drug Metabolism and Disposition” This study identified previously unknown phase I and phase II metabolites of finasteride in human bile and urine using a specialized bile collection technique and advanced mass spectrometry analysis.
19 citations
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October 2017 in “European Journal of Pharmaceutics and Biopharmaceutics” This study found that the MXD/HP-β-CD GEL formulation promoted greater hair growth and improved gene expression related to hair growth in male rats compared to MXD solution or control groups.
5 citations
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December 1991 in “Annals of the New York Academy of Sciences” Minoxidil boosts hair growth by undergoing a process in hair follicles and certain skin cells, and by increasing the production of compounds essential for hair growth and maintenance.
14 citations
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May 2005 in “Farmaco” This study developed a high performance capillary electrophoresis method, validated for both legal and illicit minoxidil-based products, to confirm minoxidil's presence alongside known impurities.
September 2018 in “Translational andrology and urology” This study explored the effects of MOTILIPERM on infertility in a rat model with varicocele and oxidative stress, reporting its potential therapeutic efficacy.
3 citations
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May 2025 in “Lasers in Surgery and Medicine” This study suggested that MRF may support skin regeneration and rejuvenation by promoting collagen synthesis and regulating factors involved in fibroblast activation and ECM remodeling, with preliminary findings indicating ADSCs might aid these processes.
January 2023 in “Revista Eletrônica Acervo Saúde” This integrative literature review found that oral Minoxidil is a favorable alternative for individuals intolerant to topical application, effectively treating various forms of alopecia, though side effects like increased hair growth and minor dermatological reactions are noted.
January 2020 in “Korean journal of ophthalmology/Korean Journal of Ophthalmology” This study found that minoxidil increases trabecular meshwork cell permeability, possibly via the downregulation of tight junction proteins and the generation of reactive oxygen species.
May 2024 in “Journal of biomaterials science. Polymer ed.” This study found that three-layer dissolving microneedles for delivering Minoxidil showed improved skin drug penetration and reduced irritation risk compared to traditional Minoxidil cream, suggesting a promising alternative for alopecia areata treatment.
May 2025 in “Süleyman Demirel Üniversitesi Fen Edebiyat Fakültesi Fen Dergisi” In this study, researchers found that minoxidil is compatible with excipients such as Beta-cyclodextrin and cellulose, while it is incompatible with Eudragit S 100 and mannitol, indicating potential formulation challenges in pharmaceutical applications.
4 citations
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May 2020 in “The journal of pediatrics/The Journal of pediatrics” This case report details the diagnosis of monilethrix in a 4-year-old boy, characterized by brittle hair and specific dermoscopic findings, and highlights the condition's hereditary nature and management through avoiding mechanical hair damage.
June 2024 in “BioSCIENCE” This study reviewed the use of microinfusion of microparticles (MMP®) with methotrexate for treating alopecia frontal fibrosante and found it reduced symptoms associated with the condition and improved specific scalp measurements, showing that the technique is safe and well-tolerated.