Compatibility Studies of Minoxidil with Different Excipients Using DSC, TGA, and FTIR

May 2025 in “ Süleyman Demirel Üniversitesi Fen Edebiyat Fakültesi Fen Dergisi ”

Hale Seçi̇lmi̇ş Canbay, Ramazan Altınkaya, Mahmut Doğantürk

TLDR Minoxidil is compatible with some excipients but not with others, affecting formulation choices.

This study investigated the compatibility of minoxidil with various excipients using DSC, TGA, and FTIR techniques. Minoxidil was found to be compatible with Beta-cyclodextrin, calcium phosphate dibasic, cellulose, and sodium carboxymethyl cellulose, indicating these excipients can be safely used in formulations. However, it was incompatible with Eudragit S 100, mannitol, magnesium stearate, and talc, suggesting these should be avoided due to potential adverse interactions affecting drug stability and efficacy. These findings are crucial for developing stable and effective minoxidil formulations in the pharmaceutical industry.

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