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This study found that micro-needling with cosmeceuticals or platelet-rich plasma significantly improved wrinkles, skin laxity, scar softening, and hair growth over 12 months, with minimal side effects, and that the best results occur with pigment and platelet massaging between 5 to 30 minutes post-treatment.

This study suggests that the cell membrane complex in hair cuticles contains hydrophilic regions with disulfide bonds allowing polymer uptake and hydrophobic lamella-like lipid layers.

This study found that lymphatic vessels in mice are important for hair follicle development and organization, as their depletion blocks hair growth.

This study found that TRPV3 activation in human sebocytes inhibits lipid synthesis and triggers proinflammatory cytokine expression, suggesting a role in the pathogenesis of dry skin-associated inflammatory dermatoses.

This review discusses the potential role of vascular endothelial cells as signaling niches influencing epithelial stem cell states in the skin, emphasizing the need for further exploration in this area.

Dissolvable microneedles are a promising, painless method for effective skin treatments.

This study identified miRNAs within the Dlk1-Gtl2 region on chromosome 18 as potential epigenetic regulators of lamb fur traits, with possible implications for the PI3K-AKT signaling pathway.

This study proposes a metal-organic gel-encapsulated microneedle system with antibacterial, anti-inflammatory, and pro-angiogenic properties for treating infected wounds, demonstrating potential for precise and adaptive management by targeting various stages of wound healing.

Merkel cells are abundant in facial vellus hair follicles, especially during the anagen phase.

In this study, lipo-minoxidil was found to increase vascular endothelial growth factor expression in the skin of C57BL/6 mice more than standard minoxidil formulations.

This review discusses the current research and development of mannosylerythritol lipids, particularly focusing on their potential commercial applications in cosmetics; it reports no new results.

In this study, topical administration of secretome hypoxia mesenchymal stem cells gel increased IL-10 and decreased TNF-α gene expression in a fluconazole-induced alopecia-like model in rats, with the 40 μL dose having the most significant effect.

This study found that the developed Finasteride-loaded SMEDDS improved the relative bioavailability of the drug compared to a commercial tablet, offering a promising oral delivery system for glucosteroid analogs.

This review highlights the potential of microneedles for immunotherapy, emphasizing their ability to enhance immune responses and reduce side effects through precise and stimuli-responsive delivery, especially in tumor treatment, while also noting the limitations and areas for improvement in current systems.

This review summarizes recent progress in microneedle-based drug delivery systems and discusses their potential impact on cellular mechanisms and immunization signaling pathways, highlighting the need for further development in fabrication methods.

This study found that hydrogels loaded with exosomes from bone marrow mesenchymal stem cells helped bone fracture healing by reducing inflammation, promoting blood vessel formation, and supporting bone regeneration, as confirmed in a mouse model.

This review highlights the potential of microneedles as a pediatric-friendly method for delivering proteins, vaccines, and diagnostics transdermally, noting their ability to penetrate the skin's barrier and suggesting future applications in other parts of the body.

In this study, a TGF-β mimic molecule from Heligmosomoides polygyrus was observed to enhance wound healing in mice, with improved tissue regeneration and specific immune cell recruitment without increased scarring.

This review examines the potential mechanisms by which stem cell-derived cell-free therapy may prevent skin aging, highlighting various molecular targets and pathways involved in regeneration, oxidative stress regulation, ECM preservation, cell activity modulation, and inflammation.

In this study, the proposed MSF-VMDNet, combining dual encoder networks with a multi-frequency domain mechanism, significantly outperformed existing methods in segmenting skin cancer tissues from histological slide images, achieving high accuracy with an MIoU of 95.37% and a Dice coefficient of 95.11%.

This abstract reports no new research findings; it includes an educational image of microorganisms found in a skin biopsy.

This study found that newly developed nanogels for transdermal delivery of finasteride were stable, showed excellent drug permeation through the skin, and ensured biocompatibility without causing irritation or toxicity.

In this study, hair follicle neural crest stem cell-derived exosomes, especially those overexpressing miR-214-3p, significantly promoted axon extension and nerve regeneration in both in vitro and in vivo models, suggesting a promising therapeutic strategy for peripheral nerve injuries.

This research explores developing liposomal formulations to enhance the delivery of difficult-to-absorb agents directly to hair follicles and sebaceous glands, with minoxidil and plasmid DNA as study molecules.

This study reports that ethosomal formulations, such as ethosomal acyclovir and minoxidil, improved therapeutic effectiveness by enhancing skin permeation, leading to faster healing of herpes labialis lesions and increased skin absorption compared to standard formulations.

This study found that in a testosterone-induced androgenetic alopecia mouse model, the combination of PRP-derived small extracellular vesicles and 5% minoxidil significantly improved hair follicle density and the anagen-to-telogen ratio compared to minoxidil alone, suggesting a synergistic effect that enhances hair growth.

High MUC-18/MCAM levels in blood indicate a worse outlook for melanoma patients.

This study found that sub-100 nm size solid lipid nanoparticles showed the most effective skin penetration and depth, mainly via hair follicles, in rat skin.