Imprinted Dlk1-Gtl2 Cluster miRNAs Are Potential Epigenetic Regulators of Lamb Fur Quality

October 2023 in “ BMC Genomics ”

Letian Zhang, Jiankui Wang, Ganxian Cai, Lina Ma, Zhengwei Zhao, Qing Ma, Xuemei Deng

miRNAs Dlk1-Gtl2 region chromosome 18 epigenetic regulators scapular skin PI3K-AKT signaling pathway

TLDR miRNAs in the Dlk1-Gtl2 region may improve lamb fur quality.

The study explores the role of miRNAs in the Dlk1-Gtl2 region on chromosome 18 as potential epigenetic regulators of lamb fur quality in Tan and Hu sheep. Researchers analyzed skin samples from 10 Chinese Tan sheep, including 5 newborn lambs and 5 adult ewes, identifying 32 up-regulated miRNAs in newborns, all located in the Dlk1-Gtl2 locus. These miRNAs are linked to the PI3K-AKT signaling pathway, which is associated with high-quality fur traits. The study suggests that miRNAs in the Dlk1-Gtl2 region may regulate fur development, highlighting the importance of the Dlk1-Gtl2/PI3K-AKT axis in improving lamb fur quality through genetic and ecological factors.

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