Pan-Cancer Analysis of MicroRNA Expression Profiles Highlights MicroRNAs Enriched in Normal Body Cells as Effective Suppressors of Multiple Tumor Types: A Study Based on TCGA Database

    April 2022 in “ PLoS ONE ”
    Sharif Moradi, Aryan Kamal, Hamidreza Aboulkheyr Es, Farnoosh Farhadi, Marzieh Ebrahimi, Hamidreza Chitsaz, Ali Sharifi‐Zarchi, Hossein Baharvand
    TLDR Certain microRNAs found in normal cells can effectively suppress various cancers.
    The study conducted a pan-cancer analysis using miRNA sequencing data from 14 cancer types in the TCGA database to identify miRNAs that are highly expressed in normal tissues but lowly expressed in tumors, termed 'normomiRs'. The research found that muscle-enriched miRNAs, such as miR-133a/b and miR-206, and miRNAs from the DLK1-DIO3 locus, like miR-381 and miR-411, were significant components of normomiRs. These miRNAs showed potential as tumor suppressors, with miR-206 and miR-381 demonstrating strong inhibitory effects on various cancer cell types in vitro. The study concluded that these findings support the potential of miRNA-replacement therapies as a strategy for targeting multiple tumor types.
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