Mir-325-3p Functions as a Suppressor Mirna and Inhibits the Proliferation and Metastasis of Glioma Through Targeting Foxm1

The study investigated the role of miR-325-3p in glioma, a malignant brain tumor known for high proliferation and metastasis. Researchers found that miR-325-3p was expressed at lower levels in glioma tissues compared to normal tissues. Through various assays and a xenograft model, it was demonstrated that upregulation of miR-325-3p suppressed tumor cell proliferation, migration, and invasion. The study identified FOXM1 as a target of miR-325-3p, with miR-325-3p modulating its expression. These findings suggested that miR-325-3p could inhibit glioma growth by suppressing FOXM1, presenting a potential therapeutic target for glioma treatment.