HOTTIP Mediated Therapy Resistance in Glioma Cells Involves Regulation of EMT-Related miR-10b

    March 2022 in “ Frontiers in Oncology ”
    Zhang Li, Ming Li, Pengcheng Xia, Zhiming Lu
    TLDR HOTTIP and miR-10b contribute to glioma therapy resistance by affecting cell behavior, suggesting they could be targets for treatment.
    The study explored the role of lncRNA HOTTIP in temozolomide (TMZ) resistance in glioma cells, focusing on the epithelial-mesenchymal transition (EMT) process. It was found that the TMZ-resistant glioma cell line SF268 had higher levels of HOTTIP and miR-10b compared to TMZ-sensitive lines A172 and LN229. Overexpression of HOTTIP in sensitive cells increased proliferation, migration, and EMT markers, indicating a role in therapy resistance. Silencing miR-10b reversed EMT and reduced TMZ resistance, suggesting that HOTTIP and miR-10b contribute to resistance through EMT regulation. The study highlighted the potential of targeting HOTTIP and miR-10b for overcoming TMZ resistance in glioma treatment, though further studies were needed.
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