HOTTIP Mediated Therapy Resistance in Glioma Cells Involves Regulation of EMT-Related miR-10b

The study explored the role of lncRNA HOTTIP in temozolomide (TMZ) resistance in glioma cells, focusing on the epithelial-mesenchymal transition (EMT) process. It was found that the TMZ-resistant glioma cell line SF268 had higher levels of HOTTIP and miR-10b compared to TMZ-sensitive lines A172 and LN229. Overexpression of HOTTIP in sensitive cells increased proliferation, migration, and EMT markers, indicating a role in therapy resistance. Silencing miR-10b reversed EMT and reduced TMZ resistance, suggesting that HOTTIP and miR-10b contribute to resistance through EMT regulation. The study highlighted the potential of targeting HOTTIP and miR-10b for overcoming TMZ resistance in glioma treatment, though further studies were needed.