Assessment of the Role of miR-30a-5p on the Proliferation and Apoptosis of Hair Follicle Stem Cells

October 2024 in “ Journal of Cosmetic Dermatology ”

Yiping Wang, Wentao Wu, Risheng Wang, Jinwei Chen, Xiangping Xu, Meiqi Li, Chiyu Jia, Nian Chen

miR-30a-5p hair follicle stem cells apoptosis proliferation β-catenin Wnt/β-catenin signaling pathway hair follicle development hair follicle regeneration hair stem cells Wnt signaling

TLDR Reducing miR-30a-5p helps hair follicle stem cells grow and survive.

The study explores the impact of miR-30a-5p on hair follicle stem cells (HFSCs), finding that its downregulation activates the Wnt/β-catenin signaling pathway, which promotes HFSC proliferation and inhibits apoptosis. This suggests miR-30a-5p as a potential therapeutic target for hair growth treatments. The research indicates that miR-30a-5p negatively regulates this pathway by targeting frizzled-2 mRNA, affecting hair follicle transition phases. The study proposes hydrogel microneedles for delivery but calls for further in vivo studies to fully understand miR-30a-5p's role in hair follicle regulation.

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