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This study found that using hyaluronic acid microneedles to deliver minoxidil significantly reduced hair loss in chemotherapy-induced alopecia mice, with only 10% of the dose used in topical applications.

In this study, cubosome and hexosome carriers with antimicrobial peptides showed varied efficacy, with cubosomes protecting peptides from degradation and enhancing bactericidal effects in some cases, while hexosomes lacked antimicrobial activity.

This study found that three-layer dissolving microneedles for delivering Minoxidil showed improved skin drug penetration and reduced irritation risk compared to traditional Minoxidil cream, suggesting a promising alternative for alopecia areata treatment.

This study reported that in animal studies of androgenetic alopecia, a biodegradable microneedle patch releasing glutamic acid promoted hair regeneration more effectively than daily minoxidil, with higher hair follicle counts and less frequent dosing, showing the potential for clinical application.

PLGA nanospheres in cosmetics improve skin and hair treatment effectiveness.

This review reported that green-synthesized metallic nanoparticles from agricultural waste hold promise for improving chronic wound care due to their antimicrobial, antioxidant, and regenerative properties, though challenges like biosafety and manufacturing scale need addressing for clinical use.

This study developed 3D micropatterns with magnesium silicate nanospheres that mimic vessels and hair follicles for potential use in skin regeneration by reconstructing vasculature and promoting hair growth.

This study developed dutasteride-loaded microneedle systems using a specific polymer to enhance transdermal delivery, demonstrating efficient drug release and increased accumulation in hair follicles, thus supporting their potential for treating androgenic alopecia.

In this study, penetration of FA-PLGA nanoparticles into hair follicles was observed in excised dog, rat, and porcine skin, with the deepest penetration in porcine skin, suggesting its similarity to human skin for drug delivery studies.

This study found that microneedles containing magnetic intracellular vesicles and tremella polysaccharide improved the hair microenvironment and accelerated hair regeneration in mice with androgenic alopecia.

This study found that microencapsulated dermal papilla cells implanted into mice ears led to the successful regeneration of hair follicles, with APA microencapsulations of 400µm diameter allowing effective nutrient exchange.

This review reports that cubosomes, used as drug nanocarriers in topical treatments, offer potential benefits for managing skin and eye diseases by improving bioadhesion, retention, and sustained release compared to conventional formulations, but also face manufacturing and biological challenges for effective clinical outcomes.

This study found that finasteride-loaded microspheres effectively treated androgenic alopecia in a mouse model, showing similar hair growth effects to orally-administered finasteride.

This article discusses scalp micropigmentation as a noninvasive method to conceal various forms of hair loss and scalp abnormalities and reports no clinical results; the authors highlight its safe and effective application.

A new treatment using special microneedles and a nitric oxide-releasing drug could improve hair growth and be more convenient for people with hair loss.

This review highlighted the potential of silver nanoparticles' antibacterial properties across biomedical, pharmaceutical, and dental applications, and emphasized plant-based biosynthesis methods as eco-friendly alternatives to conventional nanoparticle production despite existing toxicity concerns.

This review discusses the advancements in using "soft" colloidal nanocarriers for delivering photosensitive agents and highlights their potential applications in treating diseases like cancer, but it reports no new clinical results.

This study found that minoxidil solubilized in gelatin-containing microemulsions resulted in over 5% of the drug remaining in porcine skin, significantly more than the reference gel.

This study suggests that newly developed micro-pigment-encapsulated biodegradable microneedles accurately implant pigments in pig cadaver skin, potentially advancing scalp micro-pigmentation methods.

In this study, researchers investigated the formation of spherical crystals of minoxidil in various alcoholic solvents, discovering new types like spherulite aggregates and a unique butterfly-shaped crystal, with the spherulite aggregates showing improved powder flow properties compared to other forms.

This study observed that chitosan-decorated PS404-b-PAA63 nanoparticles may enhance skin retention and reduce permeation flux of finasteride, suggesting potential for improved transdermal delivery.

This review discusses pyrene excimer nucleic acid probes for detecting biomolecules and protein-DNA interactions and reports no new experimental findings.

This study reviews various skin models and methodologies used to assess the follicular penetration of nanoparticle-based drugs, highlighting inconsistencies that complicate comparisons and aims to establish more uniform protocols for clearer study outcomes.

This study explored the development of polymeric nanoparticles for topical spironolactone delivery, finding that larger nanoparticles (180 nm) enhanced drug targeting to hair follicles significantly more than smaller ones or non-nanoparticle formulations, offering promise for safer acne and alopecia treatments.

This article discusses a novel device for applying mediums to human and animal tissues and reports no new clinical results, focusing on its potential for precise applications and enhanced cell transplants.

In this study, a microneedle patch system using pullulan as a polymer was found to efficiently deliver finasteride, promising convenience and effectiveness in treating hair loss.

This review highlights that microneedling is an effective and flexible technique for enhancing transdermal drug delivery, with numerous applications in both cosmetic and therapeutic dermatological treatments. The researchers note that further advancements are likely to increase its efficacy and safety.

This review discusses nanoparticle systems for cancer treatment and reports no new clinical results; the authors emphasize their potential to reduce systemic toxicity and call for further development.

In this study, researchers developed injectable micropore-forming hydrogels that enhance tissue adhesion strength and promote wound healing by allowing better cell infiltration and inducing hair follicle regeneration in skin incision wound models.