56 citations
,
November 2003 in “Journal of Investigative Dermatology” This study identified altered expression of MMP-19 in the skin's epidermal layers during diseases like psoriasis and eczema, implying a role in disease processes.
21 citations
,
May 2016 in “Experimental and Therapeutic Medicine” In this study, the researchers observed that MMP-2 and MMP-9 significantly fluctuated with the hair growth cycle in mice, suggesting their important role in hair development.
9 citations
,
August 2005 in “Archives of Dermatological Research” Scalp dermal papilla and fibrous sheath cells have different MMP expression than scalp dermal fibroblasts.
9 citations
,
September 2017 in “Nanoscale Research Letters” This study found that combining TIMP-1 with graphene oxide promoted skin tissue regeneration in rats and provided sustained release of TIMP-1 over 40 days.
8 citations
,
May 2005 in “Fertility and Sterility” In this study, women with the GG polymorphism of the MMP1 gene promoter were found to have a higher likelihood of being diagnosed with polycystic ovary syndrome.
7 citations
,
May 2022 in “Indonesian Journal of Science and Technology” This study found that compounds isolated from the Etlingera alba rhizome exhibited cytotoxic and anti-metastatic activity, with potential for development against Triple-Negative Breast Cancer.
27 citations
,
September 2015 in “Drug Design Development and Therapy” This study suggests that type IV collagenases, MMP-2 and MMP-9, play important roles in the hair cycle by regulating the expression of VEGF, IGF-1, and TGF-β in mice.
November 2008 in “Medical & surgical dermatology” This study reports that a prototype device may accurately measure changes in hair quantity, diameter, and density in patients with balding by assessing the cross-sectional area of hair bundles.
3 citations
,
July 2020 in “Frontiers in Cell and Developmental Biology” This study found that the purified compound VB1 from Vitex negundo seeds may reduce UVA-induced skin aging by targeting MAPK1 and demonstrated its potential in mice.
October 2022 in “Faculty of 1000 Research Ltd” This review discusses the roles of various growth factors and cytokines in skin regeneration, highlighting their potential for future therapeutic development, and reports no new experimental findings.
38 citations
,
May 2010 in “American Journal Of Pathology” In this study, prolonged systemic administration of 17β-estradiol in castrated male mice delayed wound healing by inhibiting re-epithelialization and reducing collagen accumulation, with estrogen receptor-α likely mediating this effect.
April 2023 in “Journal of Investigative Dermatology” The study identified increased IL-24 expression in keratinocytes and fibroblasts exposed to particulate matter, contributing to skin aging by promoting conditions similar to age-related changes such as increased MMP1 expression and decreased type I collagen production.
January 2008 in “Acta Anatomica Sinica” In this study, minoxidil promoted hair follicle growth in culture by delaying catagen phase onset and possibly inhibiting TGFβ1 overexpression.
November 2022 in “Journal of Investigative Dermatology” This study reported that an ex vivo organ culture system effectively induced aging-related changes in healthy human skin, allowing testing of senolytics like tretinoin, resveratrol, and caffeine.
September 2016 in “Journal of Dermatological Science” This study found that P. cornucopiae extract showed antioxidant and protective effects on human skin fibroblasts, suggesting its potential as an antiaging agent by preventing oxidative stress-induced collagen breakdown.
September 2025 in “Journal of Applied Biological Chemistry” In a laboratory study, Grateloupia elata extract demonstrated antioxidant and anti-aging effects by scavenging free radicals, inhibiting collagenase and elastase, increasing procollagen production, and reducing MMP-1 secretion, suggesting its potential use in functional cosmetics.
363 citations
,
March 2017 in “Nature Communications” This study found that, in mouse tail epidermis, stem cells rapidly activate and regenerate new progenitors to repair wounds, with mechanisms affecting their proliferation, differentiation, and migration.
27 citations
,
August 2005 in “The journal of investigative dermatology/Journal of investigative dermatology” This study identified 12 new genes associated with the hair follicle and various stages of the hair cycle in mice, which could lead to novel targets for hair growth or depilation therapies.
27 citations
,
June 2001 in “International Journal of Dermatology” This study found that cytokine and EGF stimulation leads to increased MMP-9 production in hair follicles, a process involved in hair follicle involution associated with alopecia.
20 citations
,
September 2010 in “The journal of investigative dermatology/Journal of investigative dermatology” This study suggests that MMP-9 plays a significant role in extracellular matrix remodeling during hair canal formation in mice, as indicated by delayed hair shaft emergence and hair canal development in MMP-9 knockout mice.
16 citations
,
September 2020 in “British journal of dermatology/British journal of dermatology, Supplement” This review explores the role of neutrophil recruitment in the inflammation seen in hidradenitis suppurativa and emphasizes potential therapeutic targets within these pathways, but it reports no new clinical results.
14 citations
,
October 2021 in “Dermatology and Therapy” This study found that photoexposure significantly increased the gene expression of altered elastin, MMP12, and LOX, as well as the protein expression of tropoelastin and fibrillin-1, in skin models.
14 citations
,
December 2020 in “Journal of Investigative Dermatology” This study observed that aging leads to significant structural and biological changes in the scalp's hair follicle environment in women, which may affect hair growth.
4 citations
,
November 2022 in “Nutrients” In a study on mice, cow placenta extract showed strong antioxidant activities and reduced collagen damage, suggesting it could help delay skin aging caused by D-galactose.
4 citations
,
September 2012 in “Journal of dermatological science” The hair follicle's connective tissue is a key source of a certain collagen in human scalp skin.
3 citations
,
October 2024 in “International Journal of Molecular Sciences” This study found that subthermal CRET treatment increased keratinocyte proliferation and modulated cytokine production, affecting the inflammatory response in human keratinocytes through EGFR and ERK1/2/NF-κB pathways.
December 2025 in “International Journal of Molecular Sciences” In this study, orally administered Centella asiatica extract, standardized for asiaticoside content, significantly improved skin barrier function, elasticity, and reduced signs of UVB-induced photoaging in hairless mice, highlighting its potential as a nutricosmetic for skin health.
September 2023 in “Medicine” This study found increased infiltration of specific immune cells, such as γδ T cells and CD8+ T cells, in the bald scalp of male androgenetic alopecia patients, and identified four key immune-related genes potentially involved in hair loss development through interferon-γ signaling pathways.
July 2021 in “IntechOpen eBooks” This review discusses the potential of ginseng and its metabolites for treating hair loss and reports no new clinical findings.
40 citations
,
February 2020 in “Experimental and Therapeutic Medicine” This study found that autologous serum platelet-rich plasma improved skin quality and reduced wrinkles, texture, and pores in healthy females, partly by regulating the expression of MMP-1, tyrosinase, fibrillin, and tropoelastin.