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This study found that all lesions in mice treated with a new topical formulation, WR 279,396, healed completely without relapse, outperforming other formulations and showing no toxicity.

This study developed a new melanocyte cultivation medium without chemical mitogens, melanogenesis enhancers, or bovine products, demonstrating successful proliferation and melanotic differentiation of human melanocytes from hair follicles.

This review examined clinical studies on topical melatonin for skin protection and found strong evidence that it effectively prevents skin damage from radiation, but noted limited clear evidence for its anti-aging and hair growth benefits due to study design limitations and combined treatments.

Melatonin stops melanin production after tyrosinase action, with cyclic GMP mimicking this effect.

This study found that topical melatonin significantly improved hair density and reduced the severity of androgenetic alopecia in men and women.

This case report documented the management of a 46-year-old female with Marine-Lenhart syndrome, combining antithyroids with minimally invasive sclerotherapy to achieve euthyroidism and reduce thyroid nodule size by 58%.

This study found that mimosine dipeptide enantiomers inhibit melanogenesis and cyclooxygenase enzymes in B16F10 melanoma cells, suggesting potential for treating skin hyperpigmentation and inflammation.

This study found that melatonin treatment increased epidermal thickness, subcutaneous fat, and dermal-related factors in postmenopausal rats, suggesting benefits for skin structure after menopause.

This review discusses the mechanism of action of melatonin in various disorders and suggests its potential for designing new receptor ligands, but reports no new clinical findings.

In this study, a combined regimen of an oral supplement with Pinus pinaster, Grape seed extract, vitamins, and minerals, plus high SPF sunscreen, significantly improved mild-to-moderate facial melasma in 30 women over 84 days, reducing pigmentation and enhancing cosmetic appearance with no reported adverse effects.

This review discusses the current research and development of mannosylerythritol lipids, particularly focusing on their potential commercial applications in cosmetics; it reports no new results.

This chapter reviews existing knowledge about melatonin's MT₁ and MT₂ receptors in human tissues, discussing their established and potential functions, but reports no new clinical findings.

This study found that topical metformin was as effective as triple combination cream in reducing melasma severity, with minimal adverse events.

Mitoxantrone is effective for treating acute leukemia, especially in older patients, with a lower risk of heart damage.

This article discusses melatonin's role in mammalian coat color and its potential in melanoma treatment when used with chemotherapy, but reports no new clinical results.

This review discusses the protective effects and mechanisms of melatonin in skin and suggests potential therapeutic applications in cutaneous medicine, reporting no new clinical findings.

This study identified mefloquine as a potent inducer of lethal ER stress that effectively eliminated vemurafenib-resistant and sensitive melanoma cells, suggesting its potential for repurposing as a melanoma treatment.

This review discusses melatonin's potential in dermatology, highlighting its antioxidative, immunomodulatory, and DNA repair properties, but reports no new clinical results.

In this study, oral and topical tranexamic acid significantly improved melasma symptoms in 28 female patients, with all showing over 25% improvement and 50% achieving good improvement, while 92.86% experienced no side effects, suggesting it is an effective and safe treatment.

This article reviews various studies and suggests that melatonin, produced both naturally in the skin and applied topically, may offer significant protection against environmental damage, making it a promising candidate for skincare therapies.

This article reviews the effects of melatonin on skin pigmentation from frogs to humans and presents no new experimental findings, highlighting the need for further research into its dermatological applications.

This review summarizes the promising role of melatonin combined with nanosized carriers in drug delivery, suggesting enhanced effectiveness in treating various diseases compared to free melatonin.

This study found that 62% of neutered dogs with hair cycle arrest experienced partial to complete hair re-growth after melatonin treatment, but hair re-growth was not consistently linked to normal sex hormone levels.

This study found that Dex-loaded hyaluronic acid hydrogel microneedles significantly reduced pain in an acute inflammatory visceral pain model without sedation, suggesting a promising and patient-friendly alternative to intravenous delivery.

This study found that therapeutic isolated limb perfusion with melphalan for in-transit melanoma metastases resulted in a high response rate but was associated with some systemic toxicity, including nausea, vomiting, and transient bone marrow depression.

The study found that melatonin treatment in early postnatal cashmere goats increased both the quantity and quality of cashmere by promoting secondary hair follicle development and enhancing antioxidant enzyme activities.

In this study, researchers found that exosomes derived from Pinctada martensii mucus can effectively inhibit melanin production in melanoma cells and zebrafish without adverse effects, potentially offering a promising therapeutic strategy for treating pigmentary disorders by modulating the NF-κB signaling pathway.

This article discusses melatonin's roles in skin and hair growth, highlighting its antioxidative and anti-inflammatory properties, but reports no new clinical results.

This study found that melatonin combined with bromocryptine treatment in Spanish goats increased secondary hair follicle numbers and extended the cashmere growth phase during spring.

This study found that topically applied melatonin exerts significant anti-aging effects on human scalp skin ex vivo, including increased SIRT1 expression and reduced mTORC1 pathway activity.