Efficacy and Safety of Metformin for Melasma Treatment: A Systematic Review and Meta-Analysis

    December 2023 in “ Frontiers in Pharmacology ”
    Pajaree Mongkhon, Chidchanok Ruengorn, Ratanaporn Awiphan … Surapon Nochaiwong
    Studysummary This study found that topical metformin was as effective as triple combination cream in reducing melasma severity, with minimal adverse events.
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    Research cited in this study 3

    1. Update on Melasma—Part I: Pathogenesis Dermatology and Therapy · 2022
    2. Metformin in Dermatology: An Overview JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology · 2013
    3. Topical Application of a Protein Kinase C Inhibitor Reduces Skin and Hair Pigmentation ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2004