Cyclic Nucleotides and the Mediation of Melatonin-Induced Inhibition of Melanogenesis in Mammals
January 1981
in “
Elsevier eBooks
”
New to Melatonin? There is a guide in the encyclopedia. Read the guide → Studysummary Melatonin stops melanin production after tyrosinase action, with cyclic GMP mimicking this effect.
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The document discussed how melatonin inhibited melanogenesis in hair follicle cultures in vitro without affecting tyrosinase activity, suggesting the inhibition occurred at a post-tyrosinase step in the melanin biosynthetic pathway. It was noted that cyclic GMP mimicked melatonin's effects and could override the stimulatory effects of cyclic AMP on melanogenesis.
