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This review details the expression and diverse functions of melatonin receptors in non-neural tissues and reports no new clinical findings, emphasizing their potential as therapeutic targets across various physiological and pathological processes.

Melatonin improved sheep reproduction, being more beneficial and cost-effective in males.

This review explores the potential of microneedling as a drug delivery system for treating melasma, focusing on its mechanisms, safety, efficacy, and clinical advantages over conventional therapies like hydroquinone and lasers.

This study identified melatonin as a potential treatment for rosacea and Alzheimer's disease, suggesting it may help by modulating inflammatory and vascular signaling pathways.

This study found therapeutic isolated limb perfusion with melphalan to be effective for in-transit melanoma metastases on a limb, with a high response rate and transient systemic toxicity.

This study found that treating cashmere goat kids with melatonin significantly increased secondary hair follicle density, improving cashmere quality and yield, likely through mechanisms involving the MAPK signaling pathway.

This study found that melatonin supplementation significantly promoted hair regeneration in a hair depilation mouse model by up-regulating the Wnt/β-catenin signaling pathway in dermal papillae and hair follicle stem cells, suggesting potential implications for human hair loss treatments.

This review provides a comprehensive overview of melatonin's physiological roles, effects, and clinical implications, but it does not present new experimental findings.

This study found that melatonin treatment in adult cashmere goats increased cashmere yield and improved fibre quality without negatively affecting the hair follicle development or cashmere production in their offspring.

This study found that melatonin at 0.2 g/L for 72 hours most effectively enhances cashmere growth in Liaoning cashmere goats by upregulating the lncRNA MTC, which activates NF-kB signaling.

This review examines the potential of nanotechnology-based drug delivery systems to enhance melatonin's therapeutic effectiveness by overcoming its biopharmaceutical limitations, summarizing recent preclinical advancements and addressing clinical translation challenges for treating various diseases.

This review discusses the protective and stress-buffering roles of melatonin in skin functions and structures but does not present new clinical findings.

This clinical trial found that topical rosuvastatin and melatonin creams significantly reduced the severity of mild to moderate plaque psoriasis over 12 weeks, with a satisfactory safety profile.

This study introduced a novel in vitro assay for tracking melanosome transfer between melanocytes and keratinocytes, facilitating the quantification of melanin transfer and supporting the role of filopodia as a conduit.

In this study, mannosylerythritol lipids from soybean oil notably increased fibroblast and papilla cell viability, suggesting potential as a hair growth agent.

In this study, researchers observed that melatonin-mediated LncRNA MTC in Liaoning cashmere goat skin fibroblasts enhances cell proliferation by interacting with the GSTM1 protein, affecting its complex formation with ASK1 and thereby inhibiting apoptosis, which may be relevant for improving cashmere growth.

Giving melatonin to sheep before the non-breeding season can improve their chances of reproducing in northwest Mexico.

This review highlights the potential of using melatonin-loaded nanocarriers to enhance drug delivery efficiency and reduce side effects, emphasizing their promise in treating various diseases through targeted and precise delivery methods.

Melatonin helps hair growth in women with hair loss issues.

This review explores melatonin's role in hair follicle cycles and its molecular mechanisms that enhance antioxidant capacity and modulate gene expression, offering potential strategies to improve cashmere production and treating human alopecia, according to the authors.

This research reported that melatonin may serve as a potential treatment for both rosacea and Alzheimer's disease by regulating inflammation and vascular signaling pathways, demonstrating effectiveness in reducing symptoms associated with rosacea-like skin lesions in experimental settings.

This study found that the monophasic oral contraceptive ethinylestradiol/chlormadinone acetate was more effective in treating mild to moderate papulopustular acne in women than ethinylestradiol/levonorgestrel.

This study reports the development of a microemulsion using Momordica charantia extract, which demonstrated strong antioxidant and 5α-reductase inhibitory activity, potentially aiding hair loss management. The microemulsion was stable over 12 weeks, suggesting its future potential for cosmetic or pharmacological applications.

This study found that melatonin enhanced whisker growth in vitro and identified MT1 receptor presence in the granular layer of mouse epidermis and the outer root sheath, suggesting potential for hair growth treatment.

This study found that hexane extracts of Nostoc verrucosum significantly inhibited melanin synthesis in melanoma cells and demonstrated antioxidant activity, suggesting potential use in developing cosmetic and functional food products.

This research found that melatonin plays a protective and modulatory role in skin biology, reducing UV damage and chemotherapy-induced hair follicle cell harm in human organ culture models.

This study found that silencing SRD5A2 and applying melatonin significantly boosted proliferation and migration of human hair follicle stem cells without causing differentiation, while increasing MT1 expression and reducing 5-alpha-reductase levels.

This study found that the 11R-No. 10 peptide, delivered transdermally, significantly inhibited melanogenesis and produced a whitening effect in a UV-induced sun-tanning guinea pig model without cytotoxicity.

This study found that 18 mg melatonin implants did not significantly prevent recurrence of canine flank alopecia compared to placebo in dogs, though the treatment was well-tolerated, with no evidence of improved efficacy.