The Efficacy of Subcutaneous Slow-Release Melatonin Implants in the Prevention of Canine Flank Alopecia Recurrence Is Uncertain: A Double-Blind, Randomized, Placebo-Controlled Study

This double-blind, randomized, placebo-controlled study evaluated the effectiveness of an 18 mg subcutaneous slow-release melatonin implant in preventing the recurrence of canine flank alopecia (CFA) in 17 dogs. The results showed no significant difference in treatment efficacy between the melatonin and placebo groups. Some dogs in the melatonin group experienced mild swelling at the injection site, which resolved within 4 weeks. The study concluded that while the melatonin implant was safe and well-tolerated, it did not effectively prevent CFA recurrence. Further research with larger sample sizes is needed to determine the optimal dosage and preventative effect of these implants in young dogs before CFA becomes permanent.