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Did you mean Placebo-Controlled?

Glossary Placebo-Controlled

comparison involves an inactive substance to test treatment efficacy

A placebo-controlled study is a type of clinical trial where one group of participants receives the experimental treatment, while another group receives a placebo—a substance with no therapeutic effect, often a sugar pill. This design helps researchers determine the actual effectiveness of the treatment by comparing outcomes between the treated group and the placebo group, thereby accounting for the placebo effect, where participants may experience perceived or actual improvements in their condition simply because they believe they are receiving treatment.

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Research

5 / 1000+ results

research A double-blind, placebo-controlled study of inositol in trichotillomania

18 citations , November 2016 in “International clinical psychopharmacology”

This study found that in a 10-week trial, inositol did not significantly reduce trichotillomania symptoms compared to placebo, although 42.1% of inositol-treated patients felt 'much or very much improved' at the study's end.

Sesquiterpene-Enriched Extract of Curcuma Aeruginosa Roxb. Retards Axillary Hair Growth: A Randomized, Placebo-Controlled, Double-Blind Study

research Sesquiterpene-Enriched Extract of Curcuma aeruginosa Roxb. Retards Axillary Hair Growth: A Randomised, Placebo-Controlled, Double-Blind Study

5 citations , January 2018 in “Skin Pharmacology and Physiology”

This study found that a high sesquiterpene C. aeruginosa extract significantly reduced axillary hair growth in women compared to placebo with no apparent adverse effects.

The Efficacy of Subcutaneous Slow-Release Melatonin Implants in the Prevention of Canine Flank Alopecia Recurrence Is Uncertain: A Double-Blind, Randomized, Placebo-Controlled Study

research The efficacy of subcutaneous slow‐release melatonin implants in the prevention of canine flank alopecia recurrence is uncertain: A double‐blind, randomized, placebo‐controlled study

3 citations , September 2022 in “Veterinary Dermatology”

This study found that 18 mg melatonin implants did not significantly prevent recurrence of canine flank alopecia compared to placebo in dogs, though the treatment was well-tolerated, with no evidence of improved efficacy.

LB1139 AMP-303 Injectable Treatment for Androgenetic Alopecia: A Multicenter, Randomized, Placebo-Controlled Feasibility Study of a Novel Polysaccharide

research LB1139 AMP-303 injectable treatment for androgenetic alopecia: A multicenter, randomized, placebo-controlled feasibility study of a novel polysaccharide

July 2025 in “Journal of Investigative Dermatology”

In this study, AMP-303 injections demonstrated a trend toward increasing non-vellus hair count in men with mild to moderate androgenetic alopecia, notably showing a 14.5% peak increase at 60 days compared to saline, with effects lasting up to five months.

Supplementary Material for: Sesquiterpene-Enriched Extract of Curcuma Aeruginosa Roxb. Retards Axillary Hair Growth: A Randomised, Placebo-Controlled, Double-Blind Study

research Supplementary Material for: Sesquiterpene-Enriched Extract of Curcuma aeruginosa Roxb. Retards Axillary Hair Growth: A Randomised, Placebo-Controlled, Double-Blind Study

January 2018 in “Figshare”

This study found that a high-sesquiterpene extract from Curcuma aeruginosa slowed axillary hair growth in women by 22% compared to placebo over 12 weeks, with results delayed by 6 weeks, and participants reported satisfaction without adverse effects.

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Community Join

5 / 848 results

community Korean Laser Helmet has a 44% increase in hair growth vs 0% growth in placebo in a double-blinded randomized controlled clinical trial.

3037 upvotes 11 months ago

A Korean laser helmet increases hair growth by 44% compared to a placebo. Users discuss its cost-effectiveness, clinical support, and compare it to treatments like finasteride and minoxidil, focusing on wavelength and energy density.

community Pumkin Seed Oil 400mg/day oral, 6 month Randomized, Double-Blind, Placebo-Controlled Trial (N=76)

4 upvotes 4 years ago

Pumpkin seed oil may increase hair count but not thickness, though its effectiveness is debated. Some suggest using topical finasteride or saw palmetto instead.

community Reason why placebo group got regrow on trial phase 3

in Chat 16 upvotes 2 years ago

Placebo hair regrowth might be influenced by propylene glycol in lotions or participants lying about using other treatments like minoxidil, finasteride, or microneedling. Being part of a study can also improve hair health due to lifestyle changes.

community Heads Up on Future Study: "Influence of Creatine Monohydrate Supplementation on Androgens and Global Hair Assessments"

22 upvotes 6 years ago

Creatine supplementation may increase DHT levels, potentially affecting hair loss. A study is examining this effect, with participants taking 5 grams of creatine daily for six months.

community Recent (April 2025) study directly addressing whether creatine use causes hair loss (it doesn't)

56 upvotes 1 year ago

Creatine does not cause hair loss, but it may accelerate it in those predisposed to male pattern baldness. The study suggests that creatine does not affect DHT or hair loss, but individual reactions may vary.

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Learn

7 / 11 results

learn Melatonin

hormone commonly taken for sleep aid has some topical benefits for hair

Is melatonin better as a supplement or applied to the scalp? No study has compared oral and topical melatonin head to head. Topical melatonin has one small placebo-controlled pilot trial in 40 women plus a set of mostly uncontrolled studies of a cosmetic solution; oral melatonin has no published hair-loss trial at all.
Melatonin: Does it work the same for men and women? No trial has compared melatonin's effect on hair in men versus women. The only placebo-controlled scalp study enrolled 40 women, and the single reported sex difference — shedding fell in women but not men — comes from one uncontrolled 60-person observation, so any difference is unestablished.
Melatonin: Can it be combined with other treatments like minoxidil or Redensyl? No published trial has tested melatonin together with minoxidil or Redensyl, and no interaction study exists — so the combination is untested rather than shown to be safe. The melatonin scalp evidence on its own is one small placebo-controlled trial plus several uncontrolled studies.

learn Botox

How does Botox target the tension that may be blocking your hair growth? Botox for hair loss is experimental and off-label: one small open-label pilot study of 50 men reported an 18% hair-count increase, but there is no placebo-controlled trial and the proposed scalp blood-flow mechanism has never been measured in patients.

learn Finasteride

What does finasteride do to the female body? Find out its side effects. Finasteride is not approved for hair loss in women anywhere; the one controlled trial, in 137 postmenopausal women at 1 mg daily, found no benefit over placebo, while smaller uncontrolled studies at higher off-label doses report some improvement. It is contraindicated in pregnancy and crushed or broken tablets must not be handled.

learn Follistatin

glycoprotein that inhibits TGF-β and promotes hair growth by antagonizing activin

learn Procyanidin

bioflavonoid found in plants with antioxidant and hair stimulating properties

learn sh-Polypeptide-7

learn Neem Oil

natural substance from Neem tree with medicinal and pesticidal properties

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