Bioinformatics And Network Pharmacology Identify The Therapeutic Role And Potential Mechanism Of Melatonin In Alzheimer's Disease And Rosacea
November 2021
in “
OPAL (Open@LaTrobe) (La Trobe University)
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New to Melatonin? There is a guide in the encyclopedia. Read the guide → Studysummary This study identified melatonin as a potential treatment for rosacea and Alzheimer's disease, suggesting it may help by modulating inflammatory and vascular signaling pathways.
Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
The study investigated the link between rosacea and Alzheimer's disease (AD), finding 747 overlapping differentially expressed genes related to inflammation, metabolism, and apoptosis. Using bioinformatics and network pharmacology, melatonin (MLT) was identified as a potential treatment for both conditions. MLT was associated with 19 pharmacological targets and influenced inflammatory and vascular signaling pathways. Experiments showed that MLT improved rosacea-like skin lesions by reducing inflammatory cytokine secretion and inhibiting HUVEC cell migration. The study concluded that MLT could effectively treat rosacea and AD by regulating inflammation and angiogenesis.
