29 citations
,
January 2013 in “International Journal of Medical Sciences” This study found that Wnt10b promotes melanocyte maturation and pigmentation in the hair bulbs of mice by activating canonical Wnt signaling.
29 citations
,
February 2018 in “European Journal of Immunology” In this study, Treg depletion impaired skin wound healing in mice, potentially by altering the cytokine environment and expanding certain T-cell populations, disrupting the normal healing process.
24 citations
,
October 2016 in “Oncotarget” This study found that finasteride was associated with more reproductive adverse effects, including sexual dysfunction in men and fetal harm in women, compared to minoxidil in reported alopecia cases.
7 citations
,
August 2017 in “Journal of dermatological science” This study found that sorafenib increased mast cell number and degranulation in skin, suggesting PI3K signaling and SCF production may underlie its adverse cutaneous reactions.
7 citations
,
December 2011 in “Annals of anatomy” This study found that involucrin likely plays a key role in forming the cornified material of the medulla and inner root sheath of human hair, contributing to its mechanical strength.
6 citations
,
August 2007 in “Journal of Surgical Research” In this study, constitutive expression of Del1 in mice did not affect wound healing but was associated with increased hair growth following anagen induction.
4 citations
,
January 2017 in “Biological & pharmaceutical bulletin” This study found that inhibiting arachidonate 12-lipoxygenase (ALOX12) may enhance hair cuticle maturation by increasing S100A3 protein citrullination and promoting cuticular differentiation in isolated human hair follicles.
2 citations
,
February 2022 in “Journal of Pharmacy and Pharmacology” In this study, two methotrexate-loaded liquid crystal formulations for topical application showed immunomodulatory effects and induced skin changes in mice with imiquimod-induced psoriasis.
1 citations
,
December 2025 in “Journal of Investigative Dermatology” Photocrosslinkable biomaterials can improve wound healing by controlling mechanical environments.
1 citations
,
October 2025 in “International Journal of Nanomedicine” This review explores the potential for using exosomes in treating autoimmune skin diseases and promoting skin regeneration, highlighting current applications, delivery methods, and ongoing clinical trials while also identifying challenges and future research directions within dermatology.
1 citations
,
March 2019 in “KnE life sciences” This case report suggests that human dermal papillae conditioned media may accelerate wound healing in congenital aplasia cutis due to varicella infection.
June 2026 in “Scientific Reports” This study found that nestin-expressing hair follicle-derived cells express higher levels of certain neurotrophic factors and neural markers, indicating potential for neuroregenerative therapy applications.
May 2026 in “Frontiers in Cell and Developmental Biology” This review discusses hair follicle organoids as emerging models for studying hair biology and disorders, emphasizing their promise for bridging basic research and clinical applications, but reports no new results.
This study demonstrates that a novel autologous hair follicle-derived epithelial sheet can effectively repigment skin in patients with stable vitiligo, offering a potential new treatment option.
This study found that a mesenchymal stromal cell-derived regenerative extracellular matrix (rECM) significantly accelerated wound closure and improved healing in diabetic mice, also enhancing nerve and blood vessel formation compared to controls.
July 1980 in “Journal of The American Academy of Dermatology” The conference concluded that understanding hair and nail disorders is important, iron deficiency may be linked to hair loss, and while some treatments for skin conditions are effective, they may have risks and high costs.
40 citations
,
August 2010 in “Archives of dermatology” This case report describes the youngest known patient with viral-associated trichodysplasia of immunosuppression, where systemic valganciclovir therapy improved facial papule eruptions following cardiac transplantation.
18 citations
,
February 2006 in “Brain & development” This case study reports successful treatment of a 19-year-old with Satoyoshi syndrome using a combination of carbamazepine, methotrexate, prednisolone, and sex-steroids, improving muscle spasms, alopecia, and quality of life.
86 citations
,
October 2005 in “Experimental Dermatology” This review explores the role of Foxn1 in mammalian skin biology, discussing its influence on hair follicle function and the potential for further research to enhance understanding of epithelial differentiation.
49 citations
,
January 2010 in “International Journal of Pediatric Endocrinology” This review covers the pathophysiology, diagnosis, and treatment of nonclassic congenital adrenal hyperplasia due to P450c21, but it reports no new clinical results.
47 citations
,
March 2019 in “Journal of immunology research” This review discusses the effects of valproic acid on immune cell activation and gene expression, potentially influencing infection outcomes and suggesting its promise for autoimmune and hypersensitivity condition management.
31 citations
,
January 2018 in “Pediatric annals” This article reviews the characteristics, diagnosis, and management of premature adrenarche and suggests it may predict future ovarian hyperandrogenism in some adolescents; no new clinical results are reported.
31 citations
,
November 2015 in “PloS one” In this study, modulating Tyrosinase expression altered mouse coat color by affecting melanosome accumulation, indicating that melanosome maturity plays a role in determining skin and hair color beyond total melanin content.
30 citations
,
June 1993 in “The Journal of Cell Biology” This study found that transgenic mice expressing a mutant E1a oncoprotein in their skin had disturbed hair follicle maturation but did not show increased tumor development or proliferation.
2 citations
,
July 2022 in “Stem cell research & therapy” This study found that a large number of pelage hair follicle mesenchymal stem cells can be efficiently isolated using two-step Ficoll Density Gradient Sedimentation, promoting hair growth by secreting exosomes in mice.
February 2023 in “IntechOpen eBooks” This article discusses the various administration methods and considerations for testosterone replacement therapy, highlighting the importance of individualized therapeutic monitoring and potential adverse effects, but reports no new clinical results.
August 2023 in “Innovare journal of Ayurvedic sciences” In this in vitro study, methanolic extracts of Mangifera indica and Hibiscus rosa-sinensis demonstrated significant inhibitory activity on α-amylase and α-glucosidase enzymes, suggesting their potential usefulness in diabetes management due to their comparable effects to the standard drug acarbose.
124 citations
,
January 2012 in “Journal of Allergy and Clinical Immunology” This study found that activation of cannabinoid 1 receptors in human scalp hair follicles may limit excessive mast cell activation and maturation, suggesting a potential therapeutic strategy for managing MC-dependent skin diseases.
23 citations
,
January 1986 This review discusses the chemical stability of protein envelopes found in the epidermis and other stratified squamous epithelia, but reports no new clinical results.
1 citations
,
September 2025 in “Molecules” This study comparatively evaluated different extraction techniques for Schinus terebinthifolius Raddi leaf extracts and found that conventional extraction with ethanol yielded the highest antioxidant activity and beneficial effects on skin cell viability, supporting its potential use in sustainable cosmeceutical formulations targeting skin aging.