Hypoglycemic Potential of Hibiscus Rosa-Sinensis and Mangifera Indica Leaves by In Vitro Methods

The study conducted in vitro tests to examine the potential inhibitory activity of extracts from Mangifera indica (MI) and Hibiscus rosa-sinensis on α-amylase and α-glucosidase enzymes, which are related to diabetes management. The methanolic extracts of MI and H. rosa-sinensis showed significant inhibitory activity on both enzymes. At a concentration of 100 μg/mL, the inhibitory effect was up to 89% and 90% for α-amylase, and 89% and 91% for α-glucosidase, in MI and H. rosa-sinensis respectively. These results were comparable to the standard acarbose (94% at 100 μg/mL). The study concluded that MI and H. rosa-sinensis extracts exhibit considerable α-amylase and α-glucosidase inhibitory activity, supporting their use in ethno medicines for diabetes management.