21 citations
,
January 1945 in “Journal of Nutrition” Biotin deficiency in monkeys causes fur and skin issues, but 20 μg of biotin daily can prevent or cure it.
20 citations
,
January 2002 in “Laboratory Animals” This study identified a compound heterozygous mutation in a hairless rhesus macaque, which was associated with skin abnormalities similar to those in hairless mice and humans with APL.
13 citations
,
April 1994 in “Journal of Investigative Dermatology” Androgen receptors found in monkey scalps, similar to humans, affect hair growth.
11 citations
,
February 2011 in “Current Zoology” The researchers reported that alopecia is common in Japanese macaques, particularly adult females, and varies seasonally and between different populations, with a new scoring system proposed for monitoring.
4 citations
,
April 2016 in “American Journal of Primatology” This study found significant differences in alopecia rates among rhesus macaques based on their previous housing facilities, suggesting that factors beyond current environment may influence alopecia.
2 citations
,
January 2009 This study found that the hair cortisol measurement procedure was reliable, unaffected by the choice of tubes, and that hair cortisol concentration correlated moderately with the number of intense aggressions experienced.
November 2025 in “F1000Research” This study observed significant differences in skin fungal communities between healthy and alopecic cynomolgus macaques, suggesting certain microorganisms may be associated with alopecia in these primates.
May 2023 in “General and comparative endocrinology” This study found that hair cortisol concentrations in rhesus macaques were not significantly correlated with hair growth rate, suggesting that cortisol-mediated inhibition of hair growth does not explain higher cortisol levels within the non-stress range.
March 2021 in “Research Square (Research Square)” This study found that stress is likely the main cause of symmetrical alopecia in Formosan macaques, with higher stress hormone levels observed in affected individuals.
This study observed that the development of the pars intermedia in long-tailed macaques is closely associated with changes in skin pigmentation during pre- and postnatal periods through melanocyte-stimulating hormone and ACTH activity.
72 citations
,
March 2013 in “Primates” In this study, the isotopic fractionation between tissues and diets of captive Japanese macaques was quantified, particularly noting hair's response to diet changes in controlled conditions, but these findings underscore the complexity of reconstructing long-term dietary history.
11 citations
,
May 1990 in “Journal of Dermatological Science” In this animal study, topical diazoxide treatment led to increased hair thickness and follicle growth in bald stumptailed macaques without causing notable systemic side effects.
9 citations
,
March 2023 in “GeroScience”
1 citations
,
June 2011 in “Journal of Genetics” Some human genetic markers work for genetic studies in pig-tailed and stump-tailed macaques, which can help in their conservation.
February 2023 in “Journal of medical primatology” In this study, pair housing of rhesus macaques after intrafacility transfer reduced some undesirable behaviors and diarrhea compared to single housing, although no cortisol level differences were observed.
March 1998 in “Journal of Dermatological Science” Combining RU58841 and minoxidil significantly increases hair growth.
67 citations
,
February 1997 in “Teratology” This study demonstrated that high oral doses of finasteride caused external genital abnormalities in male rhesus monkey fetuses, but intravenous doses did not lead to abnormalities.
34 citations
,
February 1992 in “The Journal of Clinical Endocrinology and Metabolism” In this study, the combination of finasteride and minoxidil significantly increased hair growth in balding male stumptail macaques compared to each drug alone.
19 citations
,
October 1994 in “The Journal of Clinical Endocrinology and Metabolism”
11 citations
,
October 1994 in “The Journal of Clinical Endocrinology and Metabolism” Finasteride increases hair growth, prolongs hair cycle, and lowers dihydrotestosterone levels.
This study observed that testosterone combined with hormonal contraceptives elevated hormones like estrone and testosterone, altered coagulation factors, and increased sexual behavior frequency in female capuchin monkeys.
23 citations
,
March 2016 in “American Journal of Primatology” This study found that female rhesus macaques who gained hair showed a significant reduction in hair cortisol concentrations, suggesting a connection between hair regrowth and stress levels.
6 citations
,
August 2001 in “PubMed” This review discusses the suitability of stump-tailed macaques and rodent models for studying hair growth and developing treatments for androgenetic alopecia, but reports no new experimental results.
5 citations
,
February 2011 in “Expert Opinion on Drug Discovery” This review discusses techniques and models for assessing hair growth activity but reports no new clinical findings, emphasizing the need for standardization and improved animal models.
February 2024 in “PloS one” This study found that certain nutraceuticals did not interfere with tamoxifen's inhibition of estrogen in breast cancer cells and may enhance its effects, suggesting potential as an adjuvant therapy for hair loss in patients undergoing endocrine therapy.
February 2022 in “Research Square (Research Square)” In this cell-based study, researchers found that certain nutraceuticals combined with tamoxifen may influence estrogen receptor expression, potentially offering a protective effect and promoting hair growth during breast cancer therapy.
December 2021 in “Research Square (Research Square)” This study suggests that certain nutraceuticals may enhance the inhibitory effects of tamoxifen on estrogen in breast cancer cells and potentially offer protective benefits for hair growth in patients undergoing endocrine therapy.
August 2021 in “The journal of investigative dermatology/Journal of investigative dermatology” This study explored the effects of various nutraceutical ingredients on breast cancer cell lines but found no conclusive information regarding their interaction with tamoxifen therapy.
34 citations
,
December 1991 in “Annals of the New York Academy of Sciences” The conclusion is that small hair follicles cause baldness in macaques, and treatments like antiandrogens and minoxidil can prevent hair loss and promote regrowth.
8 citations
,
October 1988 in “Clinics in dermatology” This paper discusses the lack of a genetic model for androchronogenic alopecia in rodents, noting the stumptailed macaque as a better current model due to its similarities to human male-pattern baldness; it reports no new results.