Preclinical and Clinical Development of a Penetration Enhancer SEPA 0009

    November 2005 in “ CRC Press eBooks
    Thomas Chan
    TLDR SEPA 0009 is a promising and safe skin penetration enhancer for topical use.
    The document discussed the development of SEPA 0009, a skin penetration enhancer, highlighting its preclinical and clinical progress. SEPA 0009 was designed to overcome limitations of previous enhancers, such as drug incompatibility and safety issues. Experimental data demonstrated its effectiveness in enhancing skin permeation, with early successes including scalp hair growth in balding stumptail macaques. The first clinical use of SEPA showed promise, and nonclinical evaluations supported its safety. The document concluded that while skin penetration enhancers had a long history, SEPA 0009 showed potential for routine incorporation into topical formulations due to its improved compatibility and safety profile.
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