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This study investigated the effects of YWS1903 in pregnant rats and found that high doses led to fetal growth reduction and skeletal malformations, while lower doses did not cause significant issues, establishing a no observed adverse effect level at 60 mg/kg.

This study found that GnRH-a treatment or orchiectomy, which required significantly lower doses of oral estradiol valerate, were more effective than anti-androgens like spironolactone and finasteride in achieving target hormone levels in transgender females in India.

This study found that glucocorticoid use in rheumatoid arthritis patients is associated with dose-dependent risk of Cushingoid habitus, easy bruising, skin atrophy, and impaired wound healing, while other skin adverse effects are rare at lower doses.

This study found that patients with kerion responded well to antifungal treatments, with a lower dose of prednisolone effectively reducing inflammation when systemic corticosteroids were needed.

This article discusses treatments for hirsutism and acne in women with polycystic ovary syndrome, suggesting that lower doses of current medications maintain efficacy while reducing cost and side effects, but reports no new clinical results.

This systematic review found that hair loss was more frequently observed in acne patients on isotretinoin doses ≥0.5 mg/kg/d compared to those on lower doses, suggesting dose-dependent effects.

In this study, older age and fewer hepatitis vaccinations were linked to lower HBV antibody responses in nursing staff, with antibody levels declining over five years, suggesting a potential need for booster doses.

This study observed that treatment with spironolactone significantly improved pain, inflammatory lesion count, and HS-PGA scores among female patients with hidradenitis suppurativa, suggesting its potential as an effective treatment option, even at lower doses, despite no change in Hurley stage or fistula count.

This study found that both finasteride and dutasteride significantly reduced L-DOPA-induced dyskinesia in a rat model of Parkinson's disease, with dutasteride showing greater effectiveness at lower doses.

This study found that co-applying Curcuma aeruginosa extract or essential oil with minoxidil significantly increased minoxidil's skin penetration in an ex vivo setting, suggesting an improved topical treatment strategy for androgenic alopecia with greater efficacy and the potential for lower minoxidil doses.

This study found that finasteride 1 mg per day improved hair growth and slowed hair loss in Japanese men with male pattern hair loss compared to lower doses and placebo.

In this study, researchers reviewed data on isotretinoin and concluded that delaying certain skin procedures like laser hair removal and chemical peels after isotretinoin treatment may not be necessary, though caution is advised for fully ablative treatments, and lower isotretinoin doses are recommended.

This study found that forming inclusion complexes of DPCP with HPβCD using the 3D ground mixture method enhances its anti-inflammatory activity at lower doses compared to complexes with β-CD.

This study found that applying 120L ha-1 yr-1 of SCD Probiotics to soil significantly increased soil microbial biomass and enzyme activity compared to lower doses and control, but showed no impact on auxin production.

In this study, among postmenopausal women with female androgenetic alopecia, the combination of Pygeum africanum and Serenoa repens extracts at higher doses plus MSM significantly increased total hair growth and hair resistance compared to a lower dose formulation after 16 weeks.

This study found that supplementing dog food with zinc methionyl glycinate at 160 ppm improved hair growth rate, zinc levels in plasma and hair, and hair condition more than lower doses or sulfate form.

This study aims to compare the differences in adverse reactions and efficacy between topical and oral use of minoxidil for hair growth, with a focus on newer, lower-dose oral applications originally used for hypertension.

In this randomized study, patients with early favorable Hodgkin lymphoma showed similar complete remission and survival rates whether receiving 2 or 4 cycles of ABVD and 20 Gy or 30 Gy IFRT, though reduced toxicity was associated with fewer cycles and lower radiation doses.

In this study, 1 mg/day finasteride lowered serum PSA concentration in men aged 40–60, suggesting that PSA adjustment recommendations for prostate cancer screening using 5 mg/day finasteride should also apply to this lower dose for hair loss treatment.

This study explored the effects of a 50% hydroalcoholic UPBF extract on BPH in testosterone propionate-induced rats, finding significant improvements in prostate-related parameters and lower urinary tract symptoms at a 200 mg/kg dose, suggesting potential use in BPH management.

This study found that people taking Serenoa repens for more than 14 days had a higher likelihood of serious adverse reactions, particularly when also using multiple or interacting supplements, although higher SR doses were linked to lower risk.

Long-term estrogen therapy in postmenopausal women can improve certain health markers, hair loss is common regardless of hormone use, stopping estrogen doesn't increase breast cancer risk, smoking does, and a balanced BMI is linked to lower mortality.

In this study, researchers found that triamcinolone acetonide provided earlier visual improvement in alopecia areata treatment, but by 12 weeks, both triamcinolone acetonide and betamethasone 1.75 mg/ml showed similar effectiveness compared to lower-dose betamethasone and placebo.

This study found that topical application of Korean ginseng berry promoted hair follicle development in mice, with a lower dose proving more effective than a higher dose.

This study found that in 45-year-old German men, the use of metformin, insulin, and ACE inhibitors was associated with lower PSA levels, while low dose finasteride resulted in notable PSA decrease.

This study found that metformin, insulin, and ACE inhibitors were associated with lower PSA levels, but statins did not decrease PSA, whereas low dose finasteride (1 mg) reduced PSA levels similarly to the higher 5 mg dose.

This study found that low doses of ivermectin cream enhanced wound healing and reduced scarring by modulating inflammation and growth factor levels, suggesting potential topical use for wound treatment.

Higher doses of glucocorticoids increase the risk of blood clots in asthma patients.

Minoxidil can lower blood pressure effectively and safely in emergencies.

Low doses of oral minoxidil, a hair loss treatment, can cause temporary morning swelling around the eyes, but it's not serious and can disappear with continued use or dose adjustment.