Scientific Evaluation of a Unani Pharmacopoeia-Based Formulation on BPH in Animal Model

The study evaluated the efficacy of a 50% hydroalcoholic Unani Pharmacopoeia-Based Formulation (UPBF) extract on Benign Prostatic Hyperplasia (BPH) in testosterone propionate (TP)-induced rats. The experiment involved 48 Wistar rats divided into six groups, each with eight rats. The groups were treated with different combinations of TP, finasteride, and UPBF extract at varying doses for 28 consecutive days. The study parameters included prostate weight, prostate-to-body weight ratio, histopathological investigation of the prostate, percentage of inhibition, percentage of recovery, and determination of ST and STP levels. The results showed significant improvements in both histopathological and biochemical parameters in rats treated with finasteride and UPBF extract at a dose of 200 mg/kg. The study concluded that the UPBF extract has significant effects against TP-induced BPH in rats and could be used independently in the management of BPH and lower urinary tract symptoms.