Real World Study on Oral Estradiol Treatment in Transgender Women

This study evaluated the effectiveness of oral estradiol valerate (EV) in 103 transgender females (TGF) in India, divided into three groups: those using anti-androgens, post-orchiectomy, or GnRH-a. The study found that groups using GnRH-a or post-orchiectomy required significantly lower doses of EV and were more effective in achieving target hormone levels compared to those using anti-androgens. Specifically, 32% of the overall cohort achieved target estradiol levels, and 56% achieved target testosterone levels. Groups B and C had higher success rates in reaching these targets compared to group A. The study concluded that GnRH-a or orchiectomy is more effective than anti-androgens for hormone level management in TGF, and that spironolactone and finasteride were not effective in testosterone suppression.