Suspected Adverse Reactions to Medications and Food Supplements Containing Serenoa Repens: A Worldwide Analysis of Pharmacovigilance and Phytovigilance Spontaneous Reports

July 2023 in “ Phytotherapy Research ”

Giada Crescioli, Valentina Maggini, Emanuel Raschi, Laura Augusta Gonella, Nicoletta Luxi, Ilaria Ippoliti, Valentina Di Giovanni, Roberto Bonaiuti, Niccolò Firenzuoli, Eugenia Gallo, Francesca Menniti‐Ippolito, Ugo Moretti, Gianluca Trifirò, Alfredo Vannacci, Fabio Firenzuoli, Niccolò Lombardi

Serenoa repens pharmacovigilance phytovigilance gastrointestinal system liver damage pancreatitis anticoagulants serious adverse reactions dietary supplements saw palmetto SR

Studysummary This study found that people taking Serenoa repens for more than 14 days had a higher likelihood of serious adverse reactions, particularly when also using multiple or interacting supplements, although higher SR doses were linked to lower risk.

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research Serenoa Repens Induced Erectile Dysfunction: Underdiagnosis and Phytovigilance

1 citations , November 2021 in “British Journal of Clinical Pharmacology”

This case report suggests a potential link between the intake of Serenoa repens, commonly known as Saw palmetto, and the onset of erectile dysfunction.

research Natural Hair Supplement: Friend or Foe? Saw Palmetto, A Systematic Review in Alopecia

8 citations , January 2020 in “Skin appendage disorders”

This review found that supplements containing saw palmetto may improve hair quality and density in patients with androgenetic alopecia and telogen effluvium, but more large-scale RCTs are needed for conclusive evidence.

research An Overview of Herbal Alternatives in Androgenetic Alopecia

26 citations , April 2019 in “Journal of Cosmetic Dermatology”

This review discusses the potential of herbal treatments like Saw palmetto, Green tea, and Rosemary as alternatives to conventional drugs for androgenetic alopecia, noting that these herbs may inhibit the 5-alpha-reductase enzyme and reduce hair loss with fewer side effects.

research A Preliminary Study on Topical Cetirizine in the Therapeutic Management of Androgenetic Alopecia

21 citations , June 2017 in “Journal of Dermatological Treatment”

This study found that topical cetirizine 1% significantly improved hair density and diameter in patients with androgenetic alopecia, with patients tolerating the treatment well.

research An Update on Plant-Derived Anti-Androgens

38 citations , July 2012 in “international journal of endocrinology and metabolism”

This review discusses the clinical use of anti-androgen medications and highlights emerging evidence supporting plant-derived anti-androgens like spearmint tea for managing PCOS, but reports no new clinical results.

research Acute Liver Damage Due to Serenoa Repens: A Case Report

35 citations , January 2010 in “British Journal of Clinical Pharmacology”

This case report described a probable case of acute liver injury associated with high-dose S. repens, highlighting the safety concerns of self-medicating with herbal supplements like saw palmetto.

research Serenoa Repens: Does It Have Any Role in the Management of Androgenetic Alopecia?

28 citations , January 2009 in “Journal of Cutaneous and Aesthetic Surgery”

This article discusses Serenoa repens for androgenetic alopecia and reports no strong evidence of its effectiveness, emphasizing the need for larger clinical trials.