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GlossarySustained Release (SR)

drug delivery system releasing medication slowly over time

Sustained Release (SR), also known as Extended Release (ER) or Controlled Release (CR), refers to a drug delivery system designed to release a medication slowly over time. This allows for a more consistent therapeutic effect, reduces the frequency of dosing, and can improve patient compliance by maintaining steadier drug levels in the bloodstream.

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Research

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research SRD5A3 Is Required for Converting Polyprenol to Dolichol and Is Mutated in a Congenital Glycosylation Disorder

260 citations , July 2010 in “Cell”

Mutations in the SRD5A3 gene cause a new type of glycosylation disorder by blocking the production of a molecule necessary for protein glycosylation.

research Mutations in SREBF1, Encoding Sterol Regulatory Element Binding Transcription Factor 1, Cause Autosomal-Dominant IFAP Syndrome

34 citations , July 2020 in “American journal of human genetics”

Changes in the SREBF1 gene cause a rare genetic skin and hair disorder.

research Skin-Specific Regulation of SREBP Processing and Lipid Biosynthesis by Glycerol Kinase 5

18 citations , June 2017 in “Proceedings of the National Academy of Sciences of the United States of America”

A gene called Gk5 controls lipid production in the skin and affects hair growth.

Selected Variants of the Steroid-5-Alpha-Reductase Isoforms SRD5A1 and SRD5A2 and the Sex Steroid Hormone Receptors ESR1, ESR2, and PGR: No Association with Female Pattern Hair Loss Identified

research Selected Variants of the Steroid-5-Alpha-Reductase Isoforms SRD5A1 and SRD5A2 and the Sex Steroid Hormone Receptors ESR1, ESR2, and PGR: No Association with Female Pattern Hair Loss Identified

18 citations , February 2012 in “Experimental Dermatology”

No link found between specific genes and female pattern hair loss.

research Effects on Steroid 5-Alpha Reductase Gene Expression of Thai Rice Bran Extracts and Molecular Dynamics Study on SRD5A2

14 citations , April 2021 in “Biology”

Thai rice bran extracts, especially from Tubtim Chumphae rice, can significantly reduce the activity of hair loss genes, with x-tocopherol showing potential as an anti-hair loss product.

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Community Join

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community 4 Months 1.25Fin & Top. Min, daily biotin & 1x dermaroll per week

in Update 165 upvotes 1 year ago

User shared positive results after 4 months using 1.25mg finasteride, topical minoxidil, daily biotin, and weekly dermarolling. They expressed gratitude to another user for the advice.

community 14-Month Update - FUE Hair Transplant

in Update 977 upvotes 3 years ago

A 14-month update on a FUE hair transplant, and the effects of male pattern baldness. People discussed products such as Minoxidil, finasteride, Kerastase Chronologiste shampoo and care oil, and RU58841 to help treat hair loss.

community Follow up from post on 23/02- lighting better

in Progress Pictures 282 upvotes 1 year ago

The user shared progress pictures showing hair improvement after using finasteride for 3 months and minoxidil for 5 months, with no side effects and an increase in confidence, especially with an upcoming wedding. They encourage others considering treatment to start.

community Anybody know any supplements for hair thickness and density?

in Treatment 2 upvotes 1 year ago

The conversation discusses using Adenosine and caffeine, along with a multivitamin, for hair thickness and density. Another person suggests using finasteride and minoxidil.

community Anyone experienced weight gain on dutasteride?

in Finasteride/Dutasteride 6 upvotes 3 years ago

Dutasteride can lead to increased cholesterol and liver fat. The user is reconsidering its use due to high cholesterol and lipid levels despite a healthy lifestyle.

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