Comparing the Frequency of Isotretinoin-Induced Hair Loss at <0.5 mg/kg/d Versus ≥0.5 mg/kg/d Dosing in Acne Patients: A Systematic Review

    February 2022 in “ JAAD International ”
    Yuliya Lytvyn, Katherine McDonald, Asfandyar Mufti, Jennifer Beecker
    Studysummary This systematic review found that hair loss was more frequently observed in acne patients on isotretinoin doses ≥0.5 mg/kg/d compared to those on lower doses, suggesting dose-dependent effects.
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    Research cited in this study 11

    1. Telogen Effluvium: A Review of the Literature Cureus · 2020
    2. FDA Reports of Alopecia as an Adverse Event to Isotretinoin Journal of Cutaneous Medicine and Surgery · 2019
    3. Effects of Isotretinoin on the Hair Cycle Journal of Cosmetic Dermatology · 2018
    4. Evaluation of Biophysical Skin Parameters and Assessment of Hair Growth in Patients with Acne Treated with Isotretinoin Postepy Dermatologii I Alergologii · 2013
    5. Combination of Low-Dose Isotretinoin and Pulsed Oral Azithromycin in the Management of Moderate to Severe Acne Clinical Drug Investigation · 2011
    6. Adverse Effects of Isotretinoin: A Retrospective Review of 1743 Patients Australasian Journal of Dermatology · 2010
    7. Evaluation of Clinical Adverse Effects and Laboratory Changes in Patients with Acne Vulgaris Treated with Oral Isotretinoin Anais Brasileiros de Dermatologia · 2010
    8. Drug Reactions Affecting Hair: Diagnosis Dermatologic Clinics · 2007
    9. Towards Dissecting the Pathogenesis of Retinoid-Induced Hair Loss: All-Trans Retinoic Acid Induces Premature Hair Follicle Regression by Upregulation of Transforming Growth Factor-β2 in the Dermal Papilla Journal of Investigative Dermatology · 2005
    10. Telogen Effluvium: New Concepts and Review Archives of Dermatology · 1993
    11. Telogen Effluvium: A Comprehensive Review Archives of Dermatology · 1993

    Related research 1

    1. Isotretinoin-Unresponsive Acne as a Sign of a Congenital Disorder: A Case of 21-Hydroxylase Deficiency Dermatology Reports · 2023