Association of Common Medication with Prostate-Specific Antigen Level in 45-Year-Old German Men: Results of the PROBASE Trial

    April 2019 in “ The Journal of Urology ”
    Kathleen Herkommer, Valentin H. Meissner, Zübeyde Ertilav, Martina Kron, Helga Schulwitz, Peter Albers, Christian Arsov, Markus A. Kuczyk, Florian Imkamp, Markus Hohenfellner, Boris Hadaschik, Jürgen E. Gschwend
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    TLDR Some common medications can lower PSA levels in 45-year-old German men.
    The study, conducted on 13,021 45-year-old German men from April 2014 to April 2017, investigated the effect of common medications on Prostate-Specific Antigen (PSA) levels. The results showed that the intake of metformin, insulin, and ACE inhibitors was associated with 20%, 14%, and 7% lower PSA levels, respectively. However, the use of central nervous system agents did not affect PSA levels. Interestingly, low dose finasteride therapy (1 mg), typically used for male androgenetic alopecia, was associated with a 31% decrease in PSA levels. The study concluded that the same recommendations for interpreting a PSA test in men receiving 5 mg/day finasteride should be applied to men receiving 1 mg/day finasteride.
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