Mechanisms of Ivermectin-Induced Wound Healing

The study demonstrated that ivermectin cream, particularly at lower doses (0.03–0.1%), effectively promoted wound healing in Sprague Dawley rats by reducing inflammation and enhancing growth factors like TGF-β1 and VEGF, which are essential for tissue repair. Ivermectin-treated wounds showed faster healing with minimal scarring compared to controls, including Silver Sulfadiazine. The treatment reduced exudation, edema, and hyperemia, and decreased myeloperoxidase activity, indicating less neutrophil infiltration. The study involved 100 rats and concluded that ivermectin could modulate inflammatory responses and improve healing outcomes, suggesting its potential use in treating wounds with reduced scar formation.