Role of Silver Nanoparticles in Wound Healing: Mechanisms, Efficacy, and Clinical Applications

Silver nanoparticles (AgNPs) are highlighted for their significant role in wound healing due to their antimicrobial, anti-inflammatory, and tissue-regenerating properties. They prevent infections and promote tissue repair by modulating inflammation and encouraging angiogenesis. Various AgNP-based delivery systems, such as hydrogels and nanofiber dressings, are discussed, with a focus on smart, stimuli-responsive dressings. Clinical evidence supports their effectiveness in treating chronic, burn, and surgical wounds, though safety and regulatory challenges remain. While AgNPs offer a promising alternative to traditional wound care, further research is necessary to optimize their use and ensure long-term safety.