Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This study observed that a self-emulsifying drug delivery system for finasteride significantly enhanced bioavailability in rats compared to commercial tablets, but the formulation was found to be thermodynamically unstable.

This study found that measuring certain steroids in hair can help diagnose and monitor congenital adrenal hyperplasia in Indonesian patients, offering a simple noninvasive method for developing countries.

This study reported that polyamine levels, especially N-acetyl polyamines, were higher in the vertex region of the scalp than in the occipital region in patients with male and female pattern hair loss.

This study found that after application of a testosterone cream containing 17α-methyltestosterone and testosterone propionate, these compounds could be detected in dried blood spots up to 97 hours post-application, potentially leading to sample contamination during fingertip puncture.

This case report describes a girl with Denys-Drash syndrome misdiagnosed with hyperandrogenism due to biotin interference in immunoassays, highlighting the need for awareness of laboratory result discrepancies.

This study developed a straightforward HPTLC method for detecting nicotine and cotinine in human plasma and urine, concluding that liquid-liquid extraction with methanol: chloroform: ammonia achieved optimal separation and is applicable for forensic analysis of lethal nicotine intoxication.

This study developed and validated a method using LC-ESI-MS/MS to accurately measure finasteride levels in human serum.

This review analyzed current studies on metabolite production from the medicinal fungus Cordyceps militaris, focusing on its fermentation modes and biological functions, and emphasizes the need for modern fermentation processes to enhance industrial production.

This study identified 674 differentially expressed proteins in the skin tissues of male and female Chinese merino sheep, suggesting gender-specific molecular mechanisms that may affect wool traits.

This study found that fruit extracts from certain Egyptian Sabal species demonstrated significant anti-androgenic activity and potential therapeutic effects against benign prostatic hyperplasia in rat models and cell lines.

This study found that while dutasteride significantly altered pregnane metabolism in mares during late gestation, it did not impact pregnancy outcomes, highlighting the complexity of pregnane metabolism and the necessity of LC-MS/MS for accurate measurement.

In this study, the researchers developed and evaluated a Minoxidil emulgel formulation, finding that it had a higher drug release rate compared to Minoxidil gels.

In this study, researchers observed a curvilinear relationship between loneliness and hair cortisol concentration among older adults at elevated cardiovascular risk, with cortisol levels higher at low-to-moderate loneliness and lower at higher loneliness, though results were sensitive to some data exclusions.

This study developed and validated a method for measuring stress biomarkers in hair during pregnancy, finding that glucocorticoid levels increased over trimesters while endocannabinoid levels remained constant, suggesting hair analysis as a reliable tool for monitoring stress responses in pregnant women.

This guide explores the fundamental science and practical applications of nanocrystal technologies to enhance the bioavailability of poorly water-soluble drugs, detailing synthesis methods, stability solutions, and drug delivery innovations like hydrogel composites and microneedle platforms.

This comprehensive guide from nanotechsci.com explores how nanocrystal technology enhances the bioavailability of poorly water-soluble pharmaceuticals, detailing the science behind crystallization and practical synthesis techniques, and discussing their advanced drug delivery applications across various routes.

This study developed and validated a Gas Chromatography-Flame Ionization Detection method for assessing minoxidil, which shows good precision, accuracy, and specificity for quality control and pharmacokinetic studies.

This study found that cortisol levels, a biomarker of chronic stress, significantly increased in the post-COVID-19 lockdown period compared to pre-lockdown and during-lockdown periods, especially among females and young adults, reflecting sustained psychological stress from the pandemic.

In this study, researchers developed injectable micropore-forming hydrogels that enhance tissue adhesion strength and promote wound healing by allowing better cell infiltration and inducing hair follicle regeneration in skin incision wound models.

This study successfully synthesized acetyl tetrapeptide-3 on a laboratory scale with over 56% yield and 100% purity, supporting its use in developing hair loss and scalp care products.

In this study, a flexible adhesive self-powered wound dressing promoted skin regeneration and reduced inflammation in vivo using sound wave driving, without requiring skin bending or external devices.

This study reports the development of an artificial skin membrane incorporating hair follicles, intended as an in vitro model to better estimate drug permeation with less variability than current models used in transdermal drug delivery research.

This study developed a method to measure local steroid hormone concentrations in hair, providing new insights into hormone dynamics associated with androgenetic alopecia.

This study found that combining lecithin reverse wormlike micelles with isopropyl myristate enhanced the skin permeability of a model hydrophilic drug, facilitated by interactions with sebum in hair follicles.

This study reports that dutasteride, used alone or with tamsulosin, effectively reduces acute urine retention and surgery risk in men with benign prostatic hyperplasia, and may lower prostate cancer incidence, suggesting potential chemopreventive benefits.

This study observed that both finasteride and dutasteride significantly decreased dihydrotestosterone concentrations in hair, with dutasteride showing the greatest reduction.

This review found that while about 60% of patients with alopecia areata responded to liquid nitrogen cryotherapy in existing studies, no significant efficacy difference was observed compared to intralesional steroid injections, though relapse rates may be lower with cryotherapy.

This preliminary study of Alopecia Areata identified limited expression of certain metabolic transporters and enzymes in hair follicle immune cells, providing early insight into their unique energy needs.

This review discusses the potential cosmeceutical benefits of Pontianak Aloe Vera, highlighting its use in products for skin and hair care, and reports no new results.

This study found that a hair mask made from bitter gourd effectively reduced hair loss and dandruff among participants, though the authors note the need for clinical trials and durability tests for further validation.