Anti-Androgenic Potential of the Fruit Extracts of Certain Egyptian Sabal Species and Their Genetic Variability Studies: A Metabolomic-Molecular Modeling Approach
January 2022
in “
Food & Function
”
anti-androgenic Sabal species fruit extracts testosterone LH FSH LC-HRMS secondary metabolites helasaoussazine pinoresinol tetra-O-caffeoylquinic acid 5-α-reductase-2 inhibitors S. blackburniana cytotoxicity BPH-1 cells genetic diversity SCoT markers CBDP markers benign prostatic hyperplasia luteinizing hormone follicle-stimulating hormone liquid chromatography-high resolution mass spectrometry 5-alpha-reductase-2 inhibitors start codon targeted markers composite banding pattern markers
TLDR Certain Egyptian Sabal fruit extracts may help treat anti-androgenic diseases like benign prostatic hyperplasia.
The study evaluated the anti-androgenic activity of fruit extracts from three Egyptian Sabal species in rats, revealing significant reductions in sex organ weights and testosterone levels, alongside increases in LH and FSH serum levels. Using LC-HRMS, the researchers identified secondary metabolites and conducted in silico investigations, finding helasaoussazine, pinoresinol, and tetra-O-caffeoylquinic acid as top 5-α-reductase-2 inhibitors. S. blackburniana showed selective cytotoxicity against BPH-1 cells. Genetic diversity studies confirmed the correct genotypes and highlighted the superior performance of SCoT markers over CBDP markers. The findings suggest these extracts as potential therapeutic candidates for anti-androgenic diseases like benign prostatic hyperplasia, with demonstrated safety for liver and kidney functions.
